대한한의학회지 (The Journal of Korean Medicine)
- 제28권3호통권71호
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- Pages.261-272
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- 2007
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- 1010-0695(pISSN)
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- 2288-3339(eISSN)
신경병리성 통증과 포르말린 테스트 통증 모델을 이용한 오가피(五加皮)의 효과
The effect of Acanthopanax sessiliflorus using the model of neuropathic pain and formalin-induced pain.
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Kim, Jang-Hyun
(Department of Pediatrics, College of Oriental Medicine, Dongguk University) ;
- Chang, Gyu-Tae (Department of Pediatrics, College of Oriental Medicine, Kyunghee University) ;
- Kang, Mi-Sun (Department of Pediatrics, Daeguhaany University, Pohang Oriental Hospital)
- 발행 : 2007.09.30
초록
Objectives : This study was conducted to determine the analgesic effect of Acanthopanax sessiliflorus using the model of neuropathic pain and formalin-induced pain. Methods : A model of neuropathic pain was made by injuring the tibial nerve and sural nerve while the common peroneal nerve was maintained. After 2 weeks, the Acanthopanax sessiliflorus was orally administered to rats. The author performed behavioral teststo try out mechanical allodynia using von frey filament and cold allodynia using acetone, which are calculated by counting withdrawal response on foot. Thirty minutes after the Acanthopanax sessiliflorus injection in the abdominal cavity, the formalin test was performed. 2% formalin in a volume of