Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Attenuation of streptozotocin mediated oxidative stress, hyperglycemia and toxicity in rats by treatment with B-20 drpos - a homoeopathic preparation

  • Pillai, KK (Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard(Hamdard University)) ;
  • Najmi, Abul K (Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard(Hamdard University)) ;
  • Anwer, Tarique (Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard(Hamdard University)) ;
  • Sultana, Yasmin (Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard (Hamdard University)) ;
  • Sharma, Manju (Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard(Hamdard University))
  • Published : 2007.03.31
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Abstract

The present study is aimed at finding the effect of B-20 drops, a homoeopathic formulation, in streptozotocin (STZ) induced diabetic rats. B-20 drops comprises of the constituents derived from plants and other natural sources, and are generally prescribed by the homoeopathic physician, in cases of hyperglycemia and diabetes. The elevated levels of fasting blood glucose and pancreatic lipid peroxides observed in rats treated with STZ were significantly reduced by the treatment of B-20 drops. The reduced liver glycogen contents were also brought back to near normal level by B-20 drops treatment in STZ diabetic rats. STZ induced histopathological changes in pancreas and liver was also partially reversed by B-20 drops. The findings indicate that B-20 drops help in improving the glycogen stores in the liver and prevents STZ induced damage through free radicals by decreasing the pancreatic lipid peroxides levels.

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