Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
권호 표지
DOI QR코드

DOI QR Code

Effect of a polyherbal formulation (Diarun plus) on the glycemic status modified by physiological means in non-diabetic mice and rats

  • Published : 2007.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Diarun plus, a polyherbal formulation containing herbal ingredients of folkloric Antidiabetic effect, was investigated for its effect on glycemic status in rats and mice. In contrast to conventional chemical induced diabetic animal models, changes in glycemic states were induced by physiological maneuvers. Results revealed that in euglycemic animals Diarun plus elicited little change (-10 to +10%), which was insignificant. In food deprivation/swim exercise induced hypoglycemia, Diarun plus reduced the degree of hypoglycemia in both rats and mice (from 38% to 27% in rats and 45% to 32% in mice). Similarly, the marked hyperglycemia induced by dextrose (70% in rats and 95% in mice) was reduced markedly to 8% and 25% respectively. The findings of the present study suggests that the ingredients of Diarun plus have the unique property of maintaining near euglycemic state irrespective of the altered glycemic state, and that have no significant effect in euglycemic condition.

Keywords

References

  1. Abdel Barry JA, Abdel Hassan IA, AI Hakiem MHH. (1997) Hypoglycemic and antihyperglycemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats. J. Ethnopharmacol. 58, 149-155 https://doi.org/10.1016/S0378-8741(97)00101-3
  2. Anonymous. (1976) Medicinal Plants of India, In: Satyavati GV, Raina MK, Sharma M (eds.) Indian Council of Medical Research, New Delhi, Vol. 1, pp. 147
  3. Anonymous. (2001) The Wealth of India, National Institute of Science Communication, CSIR, Dr. KS Krishnan Marg, New Delhi, Vol. 2, pp. 264
  4. Anonymous. (2002) Proceedings of National seminar on Siddha Medicine, R&D Institutions and Pharmaceutical Industries on December 2002. In: Senthilvel G, Anoop Austin, Thirugnanasambantham P, Mayisvren E, Viswanathan S, Jegadeesan M. (2002) Effect of Diarun plus, a polyherbal formulation on physiologically modified glycemic and insulinemic status in mice. Tamil University, Thanjavur, India
  5. Chopra RN, Nayar SL, Chopra IC. (1956) The Glossary of Indian Medicinal Plants. Publications and Information Directorate, Council of Scientific and Industrial Research, New Delhi, pp. 127
  6. Jose JK, Kuttan R (1995) Antioxidant activity of Emblica officinalis. J. Clin. Biochem. Nut. 19, 63-70
  7. Karunanayake EH, Welihinda J, Sirimanne SR, Sinnadorai G. (1984) Oral hypoglycaemic activity of some medicinal plants of Sri Lanka. J. Ethnopharmacol. 11, 223-231 https://doi.org/10.1016/0378-8741(84)90040-0
  8. Kohli KR, Singh RH. (1993) A clinical trial of jambu (Eugenia jambolana) in non-insulin dependent diabetes mellitus, J. Res. Ayur. Sid. 14, 89-97
  9. Nadkarni K M. Indian Materia Medica, Vol. 1, Popular Book Depot, Bombay, p. 1954
  10. Osturk Y, Alten VM, Yidizoglu Ari N. (1996) Pharmacol. Rev. 48, 68-112
  11. Rajendran NN, Thirugnanasambantham P, Parvathavarthini S, Viswanathan S, Ramaswamy S. (2001) Modulation by insulin rather than blood glucose of the pain threshold in acute physiological and flavone induced antinociception in mice. Indian J. Exp. BioI. 39, 1009-1016
  12. Reddy PRMK, Shankar Raman, Ramaswamy S. (1998) Effect of glucose on stress induced antinociception in noral mice. Indian J. Physiol. Pharmacol. 131-134
  13. Sauvaire Y, Broca C, Petit P, Jacob M, Baissac Y, Manteghetti M, Roye M, Ribes G. (1996, 1997) 4-hydroxy isoleucine: A novel insulinotropic amino acid isolated from fenugreek seeds. Phytomedicine Suppl 1, 272
  14. Senthilvel G, Jegadeesan M, Anoop Austin, Thirugnanasambantham P, Balasubramanian M, Mayisvren E. (2004) Evaluation of efficacy and tolerability of a herbal formulation (Diarun Plus) in the management of Type 2 Diabetes mellitus in Indian patients. Amala Res. Bull. 24, 57-62
  15. Yoshikawa M, Morikawa T, Matsuda H, Tanabe G, Muraoka O. (2002) Absolute stereostructure of potent alpha-glucosidase inhibitor, Salacinol, with unique thiosugar sulfonium sulfate inner salt structure from Salacia reticulata. Bioorg. Med. Chem. 10, 1547-1554 https://doi.org/10.1016/S0968-0896(01)00422-9