Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
권호 표지
DOI QR코드

DOI QR Code

Antibacterial activity of methanol extract of roots of Heracleum nepalense D Don. on bacteria causing diarrhoea

  • Bose, Sekhar K (Pharmacognosy and Phytotherapy Research Laboratory, Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Dewanjee, Saikat (Pharmacognosy and Phytotherapy Research Laboratory, Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Mandal, Subhash C (Pharmacognosy and Phytotherapy Research Laboratory, Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University)
  • Published : 2007.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Heracleum nepalense D Don. (Umbelliferae) is a small shrub having high glabrescent stem found in stream banks in Sikkim. Various medicinal properties which include antidiarrhoeal, antiseptic, anti-influenzal etc. have been attributed for this plant in the traditional system of medicine in Sikkim. In present investigation the methanol extract of roots of Heracleum nepalense was subjected for its effectiveness against both Gram-positive and Gram-negative bacteria causing diarrhoea. The roots extract was tested for its minimum inhibitory concentration (MIC) against both Gram-positive and Gram-negative organisms causing diarrhoea. Further, the zones of inhibition produced by the crude extract against few sensitive strains was measured and compared with those of standard antibiotic ciprofloxacin. It is evident that the methanol extract is very active against the bacteria causing diarrhoea at low concentrations. The antibacterial efficacy of the root extract was found to decrease in the following order against different tested bacterial strains like Shigella dysenteriae, Escherichia coli, Shigella boydii, Vibrio cholerae, Salmonella typhimurium.

Keywords

References

  1. Anonymous (1959) The Wealth of India. Vol. V: H-K, CSIR, New Delhi. pp. 350-351
  2. Asolkar LV, Kakkar KK, Chakre OJ. (1992) Second supplement to glossary of Indian Medicinal Plants with Active Principles Part-I (A-K). CSIR (PID), New Delhi. pp. 350-351
  3. Citarasu T, Venkatramalingam K, Babu MM, Jeya sekar RR, Petermarian M. (2003) Influence of the antibacterial herbs, Solanum trilobatum, andrographis paniculata and Psoralea coryfolia on the survival, growth and bacterial load of Penaeus monodon post larvae. Aquac. Int. 11, 581-595 https://doi.org/10.1023/B:AQUI.0000013322.53358.53
  4. Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN, Ray C. (1968) Screening of Indian Plants for biological activity: I. Indian J. Exp. Biol. 6, 232-247
  5. Durmaz H, Sagun E, Tarakci Z, ozgokee F. (2006) Antibacterial activity of Allium vineale, Chaerophyllum macropodum and Prangos fernlacea. Afr. J. Biotech. 5, 1795-1798
  6. Gurung B. (2002) The Medicinal plants of the Sikkim Himalaya. 1st edn. Published by Jasmine Bijoy Gurung, West Sikkim, pp. 206
  7. Kokate CK, Purohit AP, Gokhale SB. (2003) Pharmacognosy. 24th edn Nirali Prakashan. Pune. pp. 255
  8. Mandal SC, Majumdar A, Majumdar R. (2000) Antibacterial activity of Litsea glutinosa bark. Fitoterapia 71, 439 https://doi.org/10.1016/S0367-326X(00)00132-5
  9. Mandal SC, Nandy A, Pal MP, Saha BP. (2000) Evaluation of antimicrobial activity of Asperagus recemosus Willd. root. Phytother. Res. 14, 118-119 https://doi.org/10.1002/(SICI)1099-1573(200003)14:2<118::AID-PTR493>3.0.CO;2-P
  10. Mazumder R, Mandiratta T, Mandal SC, Mazumder A. (2000) Antimicrobial potency of leaf stalk extract of Curcuma longa Linn. Anc. Sci. Llife XX, 92
  11. Pal, DC, Jain SK. (1998) Tribal Medicine. 1st edn. Published by Naya Prakash, Sikkim. pp. 11
  12. Rai L, Sharma E. (1994) Medicinal Plants of the Sikkim Himalaya. 1st edn. Published by Bishen Singh Mahendra Pal Singh, Gangtok. pp. 45
  13. Tsarong, TJ. (1994) Tibetan Medicinal plants. 1st edn. Tibetan Medicinal publication, West Sikkim. pp. 95

Cited by

  1. root on production of proinflammatory cytokines vol.25, pp.15, 2011, https://doi.org/10.1080/14786410902800665
  2. : A Comprehensive Review on Its Phytochemistry, Pharmacology, and Ethnobotanical Values as a Useful Herb vol.15, pp.6, 2016, https://doi.org/10.1111/1541-4337.12222