Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Alterations of Human Autonomic Nervous System Activity on Capsaicin Ingestion, and Variants of UCP1 and β3- -adrenergic Receptor Polymorphism

캡사이신 섭취와 UCP1 과 β3- adrenergic Receptor Polymorphism의 다양성에 대한 자율신경활동의 변화

  • Ko, Ki-Jun (Dept. of Leisure Sports, Daegu Mirae College) ;
  • Shin, Ki-Ok (Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University)
  • 고기준 (한국 경산시 대구미래대학 레저스포츠학부) ;
  • 신기옥 (일본 교토시 교토대학 인간환경학 연구와 대학원 응용생리학 실험실)
  • Published : 2007.08.30
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Abstract

We investigated whether 1) capsaicin ingestion (100 mg) enhances autonomic nervous system (ANS) activities associated with thermogenic sympathetic activity as energy metabolic modulator, 2) UCP1 and ${\beta}_{3}$-AR variants of each subjects influence with ANS activity. Eight healthy males (24.7 ${\pm}$ 1.8 yr) volunteered for this study. The cardiac autonomic nervous activities evaluated by means of heart rate variability of power spectral analysis and energy metabolism were continuously measured during 5-min rest for total 90-min resting condition with placebo or capsaicin oral administration chosen at random. The results indicated that there were no significant differences in heart rate during rest between both trials. Autonomic nervous activity increased in capsaicin tablet trial, but the difference did not reach the statistical significance. Capsaicin, however, induced significantly lower respiratory gas exchange ratio at Test3 (CAP: 0.80 ${\pm}$ 0.02 vs. 0.85 ${\pm}$ 0.02), means ${\pm}$ SE, p<0.05). In conclusion, it may be suggested the capsaicin consumption as a valuable supplement for the treatment of individual with hyperlipidemia and/or obesity by improving lipolysis. Further studies will also be considered genetic variants such as UCP1 and/or ${\beta}_{3}$-AR associated with obesity.

본 연구의 목적은 1) 캡사이신 섭취 (100 mg) 가 에너지 대사 조절자로서 열발생 교감신경활동과 관련된 자율신경활동을 향상시키는지, 2) 본 연구의 대상자들의 UCP1 과 ${\beta}_{3}$-AR 유전자 다양성이 자율신경활동에 영향을 주는지를 조사한 것이다. 8명의 대상자 (24.7 ${\pm}$ 1.8 세) 가 이 실험에 자발적으로 참여하였다. 심박수변이성 파워 스펙트랄 분석에 의해 평가된 심장자율신경활동과 에너지 대사는 총 90분간 매 30분마다 5분간 측정하였으며, 캡사이신 또는 위약 그룹은 무작위로 대상자에서 섭취되었다. 본 연구의 결과에서, 두 그룹간의 안정시 심박수에서는 유의한 차이가 없었다. 자율신경활동은 캡사이신 그룹에서 증가하였으나, 통계적으로 유의한 차이는 없었다. 총 대상자중, UCP1의 GG유전자 타입을 가진 대상자는 37.5% 였다. 그러나 캡사이신 그룹은 Test3에서 측정시 호흡 교환율이 유의하게 낮았다 (CAP: 0.80 ${\pm}$ 0.02 vs. CON: 0.85 ${\pm}$ 0.02, means ${\pm}$ SE, p<0.05). 이상의 결과로서, 캡사이신 (100 mg) 의 섭취는 지방분해를 향상시킴으로서 비만 과/또는 고지혈증을 가진 개개인에서 유익한 성분임을 시사할 수 있다. 또한 자율신경에 대한 비만과 관련된 UCP1 과/또는 ${\beta}_{3}$-AR 과 같은 유전자 다양성은 앞으로의 연구에 고려되어져야 할 것이다.

Keywords

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