생명과학회지 (Journal of Life Science)

한국생명과학회 (Korean Society of Life Science)
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소포체 스트레스가 Ajuba 발현유도

Expression of Ajuba, a Novel LIM Protein, is Regulated by Endorlasmic Reticulum Stress

  • 박상미 (충남대학교 의과대학 해부학교실) ;
  • 권기상 (충남대학교 의과대학 해부학교실) ;
  • 윤은영 (농업과학기술원 농업생물부) ;
  • 구태원 (농업과학기술원 농업생물부) ;
  • 권오유 (충남대학교 의과대학 해부학교실)
  • Park, Sang-Mi (Department of Anatomy, College of medicine, Chungnam National University) ;
  • Kwon, Ki-Sang (Department of Anatomy, College of medicine, Chungnam National University) ;
  • Yun, Eun-Young (Department of Sericulture and Entomology, National Institute of Agriculture Science and Technology) ;
  • Goo, Tae-Won (Department of Sericulture and Entomology, National Institute of Agriculture Science and Technology) ;
  • Kwon, O-Yu (Department of Anatomy, College of medicine, Chungnam National University)
  • 발행 : 2007.07.30
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초록

Ajuba is a number of proteins containing cytosolic LIM domain. Its function may provide a new pathway whereby cell-cell adhesive events are transmitted to the nucleus to regulate cell proliferation and differentiation decisions. Here, Ajuba gene expression was investigated its molecular properties associated with endoplasmic reticulum (ER) stresses (tunicamycin, DTT, A23187 and BFA) which induced remarkable ex-pression of Ajuba mRNA. The mRNA half life of Ajuba was also determined, its half life of Ajuba mRNA in FRTL-5 cells was approximately 2 hr after the initial translation. Although the obvious bioligical function of Ajuba is not clear, on the base of the results, Ajuba gene expression is deeply associated with ER stresses.

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참고문헌

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