Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Helicobacter pylori and Gastric Carcinogenesis

Helicobacter pylori와 위암발생

  • Myong, You-Ho (Korea Science Academy) ;
  • Choi, Yung-Hyun (Department of Biochemistry, Dongeui University College of oriental Medicine and Department of Biomaterial Control (BK21 program), Dongeui University Graduate School)
  • 명유호 (한국과학영재학교) ;
  • 최영현 (동의대학교 한의과대학 생화학교실 및 대학원 바이오물질제어학과)
  • Published : 2007.07.30
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Abstract

Ever since the World Health Organization classified Helicobacter pylori as a class I carcinogen, a variety of discussions over the actual role of H. pylori infection in gastric carcinogenesis has existed. Although a majority of researches support the positive correlation between H. pylori infection and the development of gastric cancer, many aspects of this association are yet uncertain, and some data even suggest that there may be no correlation between H. pylori infection and gastric carcinogenesis. However, there are proofs indicating these reports underestimated the prevalence of H. pylori infection and therefore, the association of the infection and gastric adenocarcinoma. In this report, I reviewed the epidemiology of H. pylori and gastric cancer, evidence supporting and against the positive correlation of the infection and the disease, and the possible pathological role H. pylori infection may have in gastric carcinogenesis referring particular to published literature. As a conclusion, despite a few reports of a possible negative or no relationship between gastric cancer and H. pylori infection, I was able to find that H. pylori infection did have a pathological role in the development of gastric cancer.

H. pylori가 공식적인 발암인자로 지정된 이후, 많은 연구가 H. pylori감염과 위암종 발생간의 연관관계를 지지해 왔다. 비록 몇몇 연구가 위암종 발생에 대한 H. pylori 감염의 부정적인 영향에 대한 증거를 제공하기는 했지만, 이들 연구가 H. pylori 감염률을 과소평가했다는 새로운 증거들이 제시되고 있다. 이 종설에서는 위암과 H. pylori의 역학적인 생태, H. pylori 감염과 위암종 발생의 연관관계를 지지하는 증거들, 제시된 위암종 발생의 기작, 그리고 H. pylori 감염의 위암종 발생에서의 잠재적인 병리학적 역할을 기존 연구들을 바탕으로 살펴보았다. 결론적으로 H. pylori 감염은 위암종 발생과 긍정적인 연관관계를 가진다는 것을 밝힐 수 있었다.

Keywords

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