생명과학회지 (Journal of Life Science)

한국생명과학회 (Korean Society of Life Science)
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1,5,3,7-Diazadiphosphocine-1,5-Dicarboxylic Acids의 합성과 반응

Synthesis and Reaction of 1,5,3,7-Diazadiphosphocine-1,5-Dicarboxylic Acids

  • 발행 : 2007.07.30
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초록

본 연구는 MRI 조영제나 새로운 생리활성 물질을 개발키 위해 paraformaldehyde와 hypophosphorous acid를 아미노산인 glycine 혹은 glutamic acid와 함께 반응시켜 3,7-dihydroxy-3,7-dioxoperhydro-1,5,3,7-diazadiphos-phocme-1,5-diacetic acid 1 와 3,7-dihydrexy-3,7-dioxoperhydre-1,5,3,7-diazadiphos-phocme-1,5-di- (2-glutaric acid)3을 합성하였다. 그러나 aspartic acid에 의한 2-[5-(1,2-dicarboxy-ethyl)-3,7-dihydroxy-3,7-dioxo-315.715-[1,5,3,7]diazadiphosphocan-1-yl]-succinic acid 2는 얻지 못했다. 합성 된 3,7-dihydroxy-3,7-dioxoperhydro-1,5,3,7-dia-zadiphosphocine-1,5-diacetic acid 1을 산 촉매에 의한 에스테르화반응시켜 화합물 3,7-dihydroxy-3,7-dioxoper-hydro-1,5,3,7-diazadiphosphocine-1,5-diacetic acid methyl ester 4, 3,7-dihydroxy-3,7-dioxoperhydro-1,5,3,7-dia-zadiphosphocine-1,5-diacetic acid ethyl ester 5, 그리고 3,7-dihyoxy-3,74dioxoperhyo-1,5,3,7-diazadiphosphocine-1,5-diacetic acid propyl ester 6을 합성하였다. 계속해서 다양한 반응을 통해 새로운 화합물을 합성할 것이며 생리활성검색도 실시할 예정이다.

In order to synthesize new bioactive compounds and contrasting agents, reactions of glycine and glutamic acid as an animo acid with paraformaldehyde and hypophosphorous acid were executed. Products are 3,7-dihydroxy-3,7-dioxoperhydro-1,5,3,7-diazadiphosphocine-1,5-diacetic acid 1 and 3,7-dihydroxy-3,7- dioxoperhydre-1,5,3,7-diazadiphosphocine-1,5-di-(2-glu taric acid) 3. 2-[5-(1,2-Dicarboxyethyl)-3,7-dihydroxy-3,7-dioxo-315.715-[1,5,3,7] diazadiphosphocan-1-yl]-succinic acid 2 by using aspartic acid was not obtained. Esterification of 3,7- dihydroxy-3,7-dioxoperkydro-1,5,3,7-diaza-diphosphocine-1,5-diacetic acid 1 by treatment of methanol, ethanol, and propanol were executed. 3,7-Dihydroxy-3,7-dioxoperhydro-1,5,3,7-diazadiphosphocine-1,5-diacetic acid methyl ester 4, 3.7-dihydroxy-3,7-dioxoperhydro-1,5,3,f-diazadiphosphocine-1.5-diacetic acid ethyl ester 5, and 3,7-dihydroxy-3,7-dioxoperhydro-1,5,3,7-diazadiphosphocine-1,5-diacetic acid propyl ester 6 were respectively synthesized in good yields. Continuously, we will try synthesis of novel compounds and evaluation of biological activity.

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