Injection-Acupuncture Combined by Conventional Treatment in Canine Demodicosis : Case Report

개 모낭충증에 있어서 약침과 기존 치료의 병용 : 증례 보고

  • Jun, Hyung-Kyou (College of Veterinary medicine, Chungnam National University) ;
  • Han, Ji-Won (College of Veterinary medicine, Chungnam National University) ;
  • Oh, Hyun-Wook (College of Veterinary medicine, Chungnam National University) ;
  • Lee, Hyun-Hwa (College of Veterinary medicine, Chungnam National University) ;
  • Park, Bae-Kun (College of Veterinary medicine, Chungnam National University) ;
  • Park, Seong-Jun (College of Veterinary medicine, Chungnam National University) ;
  • Cho, Sung-Whan (College of Veterinary medicine, Chungnam National University) ;
  • Kim, Duck-Hwan (College of Veterinary medicine, Chungnam National University)
  • 전형규 (충남대학교 수의과대학) ;
  • 한지원 (충남대학교 수의과대학) ;
  • 오현욱 (충남대학교 수의과대학) ;
  • 이현화 (충남대학교 수의과대학) ;
  • 박배근 (충남대학교 수의과대학) ;
  • 박성준 (충남대학교 수의과대학) ;
  • 조성환 (충남대학교 수의과대학) ;
  • 김덕환 (충남대학교 수의과대학)
  • Published : 2007.09.30

Abstract

Therapeutic effect by injection-AP with antibiotics plus conventional treatment was investigated to establish a new treatment method for canine demodicosis. Three patients diagnosed into canine demodicosis were used in the present study. Injection-AP with enrofloxacin (5 mg/kg, twice a week) was made into the acupoints such as Fei Shu(BL13), Wei Zhong (BL40), Da Zhui (GV14), Zu San Li (ST36), He Gu (LI04), Qu Chi (LI11) and Sang Yin jiao(SP06) for 5 weeks. Further, they were additionally received with conventional treatments including injection of ivermectin (0.5 mg/kg, twice a week, SC) and 0.05% amitraz rinse (twice a week) for 5 weeks. The clinical symptoms (pruritus, excoriation, erythema and alopecia) were much improved by injection-AP therapy plus conventional treatment, compared by those of pre-treatment. Case 1 became to normal after 4 weeks, Case 2 became to mild after 5 weeks and Case 3 became to normal after 5 weeks. Total WBC revealed decreasing tendency with treatment in all cases, however, N/L ratios didn't show regular pattern of change with treatment. Notable changes were not histopathogically found in skin lesions of Case 1 and Case 3 except Case 2 with mild change after 5 weeks treatment, compared by those of pre-treatment, respectively. In conclusion, the present patients were cases with canine demodicosis which revealed favorable therapeutic response by injection-AP with antibiotics plus conventional treatment.

개 모낭충증의 새로운 치료법을 확립하기 위하여 항생제의 약침과 일반 치료의 병행을 이용한 치료 효과를 조사하였다. 본 연구에서는 모낭충으로 진단된 개 3두를 이용하였다. Enrofloxacin의 약침을 폐수(BL13) 위중(BL40), 대추(GV14), 족삼리(ST36), 합곡(LI04), 곡지(LI11) 및 삼음교(SP06)의 혈위에 각각 5주간 실시하였다. 또한 일반 치료법인 invermectin과 0.05% amitraz 약욕을 5주간 추가로 실시하였다. 소양증, 찰과상, 홍반 및 탈모와 같은 임상증상은 약침과 일반치료에 의해서 치료 전에 비하여 현저하게 완화되었다. Case 1은 4주 후에 완치되었고, case 2는 5주 후에 증상이 약간 잔존하였으며, 그리고 case 3은 5주 후에 완치되었다. 혈중 백혈구 수는 치료와 더불어 모든 케이스에서 감소하는 경향을 보였으나, 호중구/림프구 비율은 일정한 경향을 나타내지 않았다. 5주째 병리조직 검사 소견상에서 case 1과 case 3은 뚜렷한 병리조직학적 변화가 관찰되지 않았으나, case 2는 경도의 변화가 관찰되었다. 결론적으로 개 모낭충에 이환된 본 환축들은 항생제 약침과 일반 치료법의 병행으로 양호한 치료반응을 나타낸 증례이었다.

Keywords

References

  1. Duclos DD, Jeffers JG, Shanley KJ. Prognosis for treatment of adult-onset demodicosis in dogs: 34 cases. J Am Vet Med Assoc 1994; 204: 616-619
  2. Folz SD, Kratzer DD, Conklin RD, Nowakowski LH, Kakuk TJ, Rector DL. Chemotherapeutic treatment of naturally acquired generalized. Vet Parasitol 1983; 13: 85-93 https://doi.org/10.1016/0304-4017(83)90023-7
  3. Folz SD, Kratzer DD, Nowakowski LH, Conklin RD, Rector DL. Evaluation of a topical treatment, alone and in combination with a detergent, for generalized demodicosis. Vet Parasitol 1985; 17: 165-172 https://doi.org/10.1016/0304-4017(85)90103-7
  4. Holm BR. Efficacy of milbemycin oxime in the treatment of canine generalized demodicosis: a retrospective study of 99 dogs(1995-2000). Vet Dermatol 2003; 14: 189-195 https://doi.org/10.1046/j.1365-3164.2003.00339.x
  5. Hubscher M, Vogt L, Banzer W. Laser needle acupuncture at Neiguan (PC6) does not mediate heart rate variability in young, healthy men. Photomed Laser Surg 2007; 25: 21-25 https://doi.org/10.1089/pho.2006.2056
  6. Kim BY, Kim TH, Kim KS, Kim WB, Liu J, Song KH, Kim DH, Rogers PA. Treatment of tracheal collapse in two dogs by injection acupuncture. Vet Rec. 2006; 159:602-603 https://doi.org/10.1136/vr.159.18.602
  7. Kim SK. Canine demodicosis-a ten year retrospective study. J Vet Clin 1997; 14: 136-139
  8. Lee CY, Lee CG, Seo GW. Studies on the contact infection of canine demodicosisO. Kor J Vet Res 1992; 32: 407-412
  9. Mojzisova J, Paulik S, Bajova V, Baranova D. Immunomodulatory effect of levamisole and administration of amitraz in dogs with uncomplicated generalized demodicosis. Vet Med 1997; 42: 307-311
  10. Mueller RS. Treatment protocols for demodicosis: an evidencebased review. Vet Dermatol 2004; 15: 75-89 https://doi.org/10.1111/j.1365-3164.2004.00344.x
  11. Nelson RW, Couto CG Infectious diseases. In: small animal internal medicine 3rd ed. China: Mosby. 2003: 1229-1306
  12. Oh TH, Park HM, Youn HY, Han HR. Efficacy of ivermectin in combination treatment with amitraz in dogs with generalized demodicosis. J Vet Clin 1998; 15: 209-213
  13. Paradis M. New approaches to the treatment of canine demodicosis. Vet Clin North Am Small Anim Pract 1999; 29: 1425-1436
  14. Ristic Z, Medleau L, Paradis M, White-Weithers NE. Ivermectin for treatment of generalized demodicosis in dogs. J Am Vet Med Assoc 1995; 207: 1308-1310
  15. Schoen AM. Acupuncture for dermatologic disorders. In: Veterinary Acupuncture, 1st ed. St. Louis: Mosby 1994: 269-275
  16. Scott DW, Miller WH, Griffin CE. Parasitic skin diseases In: Small animal dermatology. 6th ed. St. Louis, Saunders 200 I: 263-268
  17. Scott DW, Miller WH, Griffin CE. Parasitic skin diseases. In: Small animal dermatology. 6th ed. St. Louis, Saunders 2001: 423-516
  18. Shipstone M. Generalised demodicosis in dogs, clinical perspective. Aust Vet J 2000; 78: 240-242 https://doi.org/10.1111/j.1751-0813.2000.tb11741.x
  19. Vas J, Aguilar I, Perea-Milia E, Mendez C. Effectiveness of acupuncture and related techniques in treating non-oncological pain in primary healthcare--an audit. Acupunct Med 2007; 25: 41-46 https://doi.org/10.1136/aim.25.1-2.41
  20. Yang YK, Rong HB, Chen HP, Tang Y. Effects of moxibustion on erectile function and NO-cGMP pathway in diabetic rats with erectile dysfunction. Zhongguo Zhen Jiu. 2007; 27: 353-356