Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Comparative Effect of Carboxymethylcellulose, Chondroitin, and Carboxymethylchitosan on Preventing Intraperitoneal Adhesion Formation in Rats

Rat에서 carboxymethylcellulose, chondroitin 및 carboxymethylchitosan의 복강유착방지 효과의 비교

  • Kwon, Young-Sam (School of Veterinary Medicine, University of Wisconsin-Madison) ;
  • Jang, Kwang-Ho (College of Veterinary Medicine, Kyungpook National University)
  • 권영삼 (위스콘신-매디슨 대학교 수의과대학) ;
  • 장광호 (경북대학교 수의과대학)
  • Published : 2007.09.30
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Abstract

This study was performed to compare the effects of carboxymethylcellulose (CMCE), chondroitin sulfate (Chondron), and carboxymethylchitosan (CMCH) on preventing intraperitoneal adhesion. As a result, the tensile strength of adhesions formed between the parietal peritoneum and the ileal serosa was significantly decreased in the groups of three different kinds of anti-adhesive agents. The distance of adhesion site was slightly increased in the treatment groups comparing control group. In the CMCH group, the inflammatory cell infiltration, collagen hyperplasia, and neovascularization were significantly lower than those of control group. It was observed that the damage at intestinal serosa was significantly decreased in the chondron and CMCH groups comparing control group. Therefore CMCH may be useful as a anti-adhesive agent in the prevention of intraperitoneal adhesion in rats.

Keywords

References

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