Effect of Postpartum Intrauterine Infusion of Povidone-iodine Solution on the Subsequent Reproductive Performance in Dairy Cows

분만 젖소의 자궁내 povidone-iodine 용액의 주입이 번식효율에 미치는 영향

  • Lew, In-Cheon (College of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Ill-Hwa (College of Veterinary Medicine, Chungbuk National University)
  • Published : 2007.09.30

Abstract

This study determined the effect of postpartum intrauterine infusion of povidone-iodine solution on the subsequent reproductive performance in dairy cows. Six hundred and fifty-eight dairy cows that were around week 4 postpartum were randomly divided into two groups: (1) Cows in treated group received an intrauterine infusion of 100 to 150 ml 2% povidone-iodine solution (treated group, n=269), or (2) Cows that received no treatment were served as the controls (control group, n=389). The cows were bred at observed estrus more than 50 days after calving. Artificial insemination (AI) was done according to the a.m.-p.m. rule. The conception to AI was determined per rectum 60 days after AI by both ultrasonographical observation and manual palpation. The intervals from calving to first service and conception ($94.2{\pm}2.7$ and $144.1{\pm}4.1$ days vs. $88.0{\pm,}2.1$ and $143.5{\pm}4.6$ days, respectively), number of services per conception ($2.0{\pm}0.1$ vs. $2.1{\pm}0.1$), and cumulative pregnancy rates within 90 and 150 days postpartum (31.9 and 61.7% vs. 29.7 and 62.1%) did not differ between the control and treated groups (P>0.05), while conception rate at first service was lower (P<0.05) in the treated group (40.5%) than in the control group (49.4%). Additionally, we could not find any effect of intrauterine infusion of povidone-iodine solution according to cow parity or calving season on the reproductive performance. These results indicate that intrauterine infusion of povidone-iodine solution at week 4 postpartum does not affect the subsequent reproductive performance in dairy cows.

Keywords

References

  1. Arthur GH, Noakes DE, Pearson H. Veterinary reproduction and obstetrics. London: Bailliere Tindall. 1989: 161-162
  2. Ayliffe TR, Noakes DE. Effects of exogenous oestrogen and experimentally induced endometritis on absorption of sodium benzylpenicillin from the cow's uterus. Vet Rec 1982; 110: 96-98 https://doi.org/10.1136/vr.110.5.96
  3. Bartlett PC, Kirk JH, Wilke MA, Kaneene JB, Mather EC. Metritis complex in Michigan Holstein-Friesian cattle: incidence, descriptive epidemiology and estimated economic impact. Prev Vet Med 1986; 4: 235-248 https://doi.org/10.1016/0167-5877(86)90026-7
  4. Bondurant RH. Inflammation in the bovine female reproductive tract. J Anim Sci 1999; 77 (Suppl. 2): 101-110 https://doi.org/10.2527/1999.77suppl_2101x
  5. Borsberry S, Dobson H. Periparturient diseases and their effect on reproductive performance in five dairy herds. Vet Rec 1989; 124: 217-219 https://doi.org/10.1136/vr.124.9.217
  6. Cavestany D, Foote RH. Reproductive performance of Holstein cows administered GnRH analog HOE 766 (Buserelin) 26 to 34 days postpartum. J Anim Sci 1985; 61: 224-233 https://doi.org/10.2527/jas1985.611224x
  7. Correa MT, Erb H, Scarlett J. Path analysis for seven postpartum disorders of Holstein cows. J Dairy Sci 1993; 76: 1305-1312 https://doi.org/10.3168/jds.S0022-0302(93)77461-5
  8. Dhaliwal GS, Murray RD, Woldehiwet Z. Some aspects of immunology of the bovine uterus related to treatments for endometritis. Anim Reprod Sci 2001; 67: 135-152 https://doi.org/10.1016/S0378-4320(01)00124-5
  9. Etherington WG, Kelton DF, Adams JE. Reproductive performance of dairy cows following treatment with fenprostalene, dinoprost, or cloprostenol between 24 and 31 days post partum: A field trial. Theriogenology 1994; 42: 739-752 https://doi.org/10.1016/0093-691X(94)90442-L
  10. FOldi J, Kulcsar M, Pecsi A, Huyghe B, de Sa C, Lohuis JACM, Cox P, Huszenicza Gy. Bacterial complications of postpartum uterine involution in cattle. Anim Reprod Sci 2006; 96: 265-281 https://doi.org/10.1016/j.anireprosci.2006.08.006
  11. Griffin JFT, Hartigan PJ, Nunn WR. Non-specific uterine infection and bovine fertility. Infection patterns and endometritis during the first seven weeks post-partum. Theriogenology 1974; 1: 91-106 https://doi.org/10.1016/0093-691X(74)90052-1
  12. Gupta RC, Sinha AK, Krishnaswamy A. Studies on the efficacy of some post-service intrauterine infusions on the conception rate of repeat breeding cattle. Theriogenology 1983; 20: 559-564 https://doi.org/10.1016/0093-691X(83)90079-1
  13. Hussain AM, Daniel RCW, O'Boyle D. Postpartum uterine flora following normal and abnormal puerperium in cows. Theriogenology 1990; 34: 291-302 https://doi.org/10.1016/0093-691X(90)90522-U
  14. Hussain AM, Daniel RCW. Bovine normal and abnormal reproductive and endocrine functions in the postpartum period: a review. Reprod Domest Anim 1991; 26: 101-111 https://doi.org/10.1111/j.1439-0531.1991.tb01526.x
  15. Kasimanickam R, Duffield TF, Foster RA, Gartley CJ, Leslie KE, Walton JS, Johnson WH. The effect ofa single administration of cephapirin or cloprosteno1 on the reproductive performance of dairy cows with subclinical endometritis. Theriogenology 2005; 63: 818-830 https://doi.org/10.1016/j.theriogenology.2004.05.002
  16. Kim IH, Kang Ho. Risk factors for postpartum endometritis and the effect of endometritis on reproductive performance in dairy cows in Korea. J Reprod Dev 2003; 49: 485-491 https://doi.org/10.1262/jrd.49.485
  17. Kim JH, Na KJ, Yang MP. Immune responses during the peripartum period in dairy cows with postpartum endometritis. J Reprod Dev 2005; 51: 757-764 https://doi.org/10.1262/jrd.17036
  18. LeBlanc SJ, Duffield TF, Leslie KE, Bateman KG, Keefe GP, Walton JS, Johnson BJ. Defining and diagnosing postpartum clinical endometritis and its impact on reproductive performance in dairy cows. J Dairy Sci 2002; 85: 2223-2236 https://doi.org/10.3168/jds.S0022-0302(02)74302-6
  19. Lewis GS. Health problem of the postpartum cow: Uterine health and disorders. J Dairy Sci 1997; 80: 984-994 https://doi.org/10.3168/jds.S0022-0302(97)76024-7
  20. Markusfeld O. Periparturient traits in seven high dairy herds. Incidence rates, association with parity, and interrelationships among traits. J Dairy Sci 1987; 70: 158-166 https://doi.org/10.3168/jds.S0022-0302(87)79990-1
  21. Markusfeld O, Galon N, Ezra E. Body condition score, health, yield and fertility in dairy cows. Vet Rec 1997; 141: 67-72 https://doi.org/10.1136/vr.141.3.67
  22. Martinez J, Thibier M. Reproductive disorders in dairy cattle. Respective influence of herds, seasons, milk yield and parity. Theriogenology 1984; 21: 569-581 https://doi.org/10.1016/0093-691X(84)90442-4
  23. McClary DO. Bacillus stearothermophilus disk assay detection of penicillin in milk of dairy cows after postestrual intrauterine infusion. Am J Vet Res 1984; 45: 416-419
  24. Miller HV, Kimsey PB, Kendrick JW, Darren B, Doring L, Franti C, Horton J. Endometritis in cattle: Diagnosis, treatment and fertility. Bovine Prac 1980; 15: 13-23
  25. Nakao T, Moriyoshi M, Kawata K. Effect of postpartum intrauterine treatment with 2% polyvinylpyrrolidone-iodine solution on reproductive efficiency in cows. Theriogenology 1988; 30: 1033-1043
  26. Nakao T, Gamal A, Osawa T, Nakada K, Moriyoshi M, Kawata K. Postpartum plasma PGF metabolite profile in cows with dystocia and/or retained placenta, and effect of Fenprostalene on uterine involution and reproductive performance. J Vet Med Sci 1996; 59: 791-794 https://doi.org/10.1292/jvms.59.791
  27. Otero MC, Morelli L, Nader-Macias ME. Probiotic properties of vaginal lactic acid bacteria to prevent metritis in cattle. Lett Appl Microbiol 2006; 43: 91-97 https://doi.org/10.1111/j.1472-765X.2006.01914.x
  28. Paisley LG, Mickelsen WD, Anderson PB. Mechanisms and therapy for retained fetal membranes and uterine infections in cows: a review. Theriogenology 1986; 25: 353-381 https://doi.org/10.1016/0093-691X(86)90045-2
  29. Pugh DG, Lowder MQ, Wenzel GW. Retrospective analysis of the management of 78 cases of postpartum metritis in the cow. Theriogenology 1994; 42: 455-463 https://doi.org/10.1016/0093-691X(94)90683-A
  30. SAS. SAS System, Release 8.1, SAS Inst., Cary. 1999
  31. Schnyder D, Kupfer U, Zwahlen R. Changes in the endometrium of the cow after intrauterine administration of different drugs. Schweiz Arch Tierheilkd 1990; 132: 353-364
  32. Seguin BE, Morrow DA, Lewis TM. Luteolysis, luteostasis and the effects of prostaglandin $F_{2a}$ on cows after endometrial irritation. Am J Vet Res 1974; 35: 57-61
  33. Sheldon IM, Noakes DE. Comparison of three treatments for bovine endometritis. Vet Rec 1998; 23: 575-579
  34. Sheldon IM, Noakes DE, Rycroft AN, Pfeiffer DU, Dobson H. Influence of uterine bacterial contamination after parturition on ovarian dominant follicle selection and follicle growth and function in cattle. Reproduction 2002; 123: 837-845 https://doi.org/10.1530/rep.0.1230837
  35. Thurmond MC, Jameson CM, Picanso JP. Effect of intrauterine antimicrobial treatment in reducing calving-to-conception interval in cows with endometritis. J Am Vet Med Assoc 1993; 203: 1576-1578