Journal of Embryo Transfer (한국수정란이식학회지)

The Korean Society of Embryo Transfer (한국수정란이식학회)
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Evaluation of Maternal Behavior between Normal Parturition and Expected Cesarean Section in Rats

자연 분만 및 예정된 제왕절개 수술 랫드에 있어서 모성 행동의 차이에 대한 검토

  • Lee, S.K. (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Kang, H.G. (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Kim, I.W. (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Jeong, J.M. (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Hwang, D.Y. (Division of Laboratory Animal Resource, National Institute of Toxicological Research, KFDA) ;
  • Kim, C.K. (Division of Laboratory Animal Resource, National Institute of Toxicological Research, KFDA) ;
  • Chae, K.R. (Division of Laboratory Animal Resource, National Institute of Toxicological Research, KFDA) ;
  • Cho, J.S. (Division of Laboratory Animal Resource, National Institute of Toxicological Research, KFDA)
  • 이상규 (충북대하교 수의과대학 및 동물의학연구소) ;
  • 강현구 (충북대하교 수의과대학 및 동물의학연구소) ;
  • 김일화 (충북대하교 수의과대학 및 동물의학연구소) ;
  • 정재민 (충북대하교 수의과대학 및 동물의학연구소) ;
  • 황대연 (국립독성연구원 실험 동물자원실) ;
  • 김철규 (국립독성연구원 실험 동물자원실) ;
  • 채갑용 (국립독성연구원 실험 동물자원실) ;
  • 조정식 (국립독성연구원 실험 동물자원실)
  • Published : 2007.09.29
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Abstract

Oxytocin is a neurohypophyseal hormone which has multiple functions in mammals. Mainly, oxytocin regulates milk ejection and has an effect on uterine contraction and is related to maternal behavior. Maternal behavior is believed to be suppressed by stress and facilitated by oxytocin. In the cesarean section, oxytocin may be administrated into uterus to promote uterine involution. The present study aimed to test the effect of oxytocin into uterus on maternal behavior of rats with cesarean section. It was measured the effects on maternal behavior of oxytocin infused into uterus in rats with cesarean section as a stressor. In the first experiment, pup survival rate of between a control group and a group with laparotomy as a stress in natural parturition rats was compared. In the second experiment, survival rate for 2 weeks and maternal pup searching behavior (MPSV) were observed in one cesarean sectioned group without oxytocin and the other cesarean sectioned group with oxytocin. Infanticide was observed in stressed group in the first experiment while a normal maternal behavior was observed in a control one. In the second experiment, MPSV was only observed in a cesarean sectioned group with oxytocin and infanticide was observed in two groups except one rat which is thought to be affected by oxytocin as operated relatively late. This is the first study to show that the administration of oxytocin into uterus in the cesarean section is not involved in the regulation of maternal behavior in rats. In conclusion, this study proves the needs of oxytocin into brain in cesarean section related rats model and further study of maternal behavior list, like MPSV.

포유류에서 옥시토신은 다양한 기능을 가지고 있는 신경뇌하수체 호르몬이다. 옥시토신은 주로 젖의 분비를 일으키고 분만 시 자궁의 수축 및 모성 행동과 관계가 있다. 모성 행동은 스트레스에 의해 억압을 받으며 옥시토신에 의해 촉진된다. 본 연구는 제왕절개의 스트레스와 자궁내 옥시투여에 따른 모성 행동의 변화를 알아보기 위해 수행되었다. 본 실험 결과, 자연 분만 예에서 스트레스를 준 개체와 스트레스를 주지 않은 개체에서 새끼의 생존율을 비교한 결과, 스트레스를 준 군에서 새끼의 생존율이 낮아 스트레스가 모성 행동에 영향을 미친다는 것을 확인하였다. 제왕절개 수술을 실시한 예에서 옥시토신을 투여한 군은 마취의 회복 후 일정 시간이 경과한 다음 새끼를 잡아먹는 식자증이 나타난 반면, 옥시토신을 투여한 군에서는 마취에서 회복한 다음 곧바로 새끼를 확인한 다음 살해하는 행동을 보였다. 결과적으로 새끼를 관리하고자 하는 모성 행동을 발현하기 위해서는 말초에 옥시토신을 투여하는 것은 의미가 없다는 것을 확인하였으며, 분만 시 모체에 대한 스트레스는 새끼의 관리에 좋지 않은 영향을 미친다는 것을 확인하였다. 또한, 본 실험은 랫드를 대상으로 제왕절개라는 새로운 스트레스의 실험적 이용, 임상적으로 제왕절개시 수행하는 자궁 내 옥시토신 투여의 임상적 평가, 그리고 제왕절개 수술을 실시한 다음 마취 회복 후 새끼를 탐색하는 모성 행동관찰의 요인을 추가한 새로운 실험이라는데 의의가 있다.

Keywords

References

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