Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Tumorigenesis Study of Canine Adipose Derived-mesenchymal Stem Cell

개 지방세포 유래의 중간엽 줄기세포의 종양형성시험

  • Lee, Eun-Sun (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Kwon, Eun-A (Clinical Research Institute and College of Medicine, Seoul National University) ;
  • Park, Jeong-Ran (Laboratory of Stem Cell and Tumor Biology, Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Kang, Byung-Chul (Clinical Research Institute and College of Medicine, Seoul National University) ;
  • Kang, Kyung-Sun (Laboratory of Stem Cell and Tumor Biology, Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Cho, Myung-Haing (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
  • 이은선 (서울대학교 수의과대학 독성학교실) ;
  • 권은아 (서울대병원 임상의학연구소) ;
  • 박정란 (서울대학교 수의과대학 공중보건학교실) ;
  • 강병철 (서울대병원 임상의학연구소) ;
  • 강경선 (서울대학교 수의과대학 공중보건학교실) ;
  • 조명행 (서울대학교 수의과대학 독성학교실)
  • Published : 2007.09.30
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Abstract

Several recent studies demonstrated the potential of bioengineering using stem cells in regenerative medicine. Adult mesenchymal stem cells (MSCs) have the pluripotency to differentiate into cells of mesodermal origin, i.e., bone, cartilage, adipose, and muscle cells; they, therefore, have many potential clinical applications. On the other hand, stem cells possess a self-renewal capability similar to cancer cells. For safety evaluation of MSCs, in this study, we tested tumorigenecity of canine adipose derived mesenchymal stem cells (cAD-MSCs) using Balb/c-nu mice. In this study, there were no changes in mortality, clinical signs, body weights and biochemical parameters of all animals treated. In addition, there were no significant changes between control and treated groups in autopsy findings. These results indicate that cAD-MSC has no tumorigenic potential under the condition in this study.

Keywords

References

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