Food Science and Biotechnology

  • 제16권4호
  • /
  • Pages.641-645
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  • 2007
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  • 1226-7708(pISSN)
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  • 2092-6456(eISSN)
한국식품과학회 (Korean Society of Food Science and Technology)
권호 표지

Anti-Proliferative and Anti-Carcinogenic Enzyme-inducing Activities of Delphinidin in Hepatoma Cells

  • Jang, Chan-Ho (Department of Animal Science and Biotechnology, Kyungpook National University) ;
  • Lee, In-Ae (Department of Animal Science and Biotechnology, Kyungpook National University) ;
  • Lim, Hyun-Ae (Department of Animal Science and Biotechnology, Kyungpook National University) ;
  • Kim, Ju-Ryoung (Department of Animal Science and Biotechnology, Kyungpook National University) ;
  • Ha, Young-Ran (Department of Animal Science and Biotechnology, Kyungpook National University) ;
  • Yu, Hoon (Department of Food and Nutrition, Sookmyung Women's University) ;
  • Sung, Mi-Kyung (Department of Pharmacology and Dental Therapeutics, College of Dentistry, Chosun University) ;
  • Kim, Jong-Sang (Department of Animal Science and Biotechnology, Kyungpook National University)
  • 발행 : 2007.08.31
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초록

Delphinidin, an aglycone form of anthocyanins, was demonstrated to have anti-carcinogenic potential. The compound at $50\;{\mu}g/mL$ caused a significant increase of quinone reductase activity, an anti-carcinogenic marker enzyme, in mouse hepatoma cell lines (Hepa1c1c7 and BPRc1). Delphinidin enhanced the expression of other detoxifying or antioxidant enzymes including glutathione s-transferase, gamma-glutamylcysteine synthetase, heme oxygenase 1, and glutathione reductase. It suppressed the proliferation of murine hepatoma cells in a dose-dependent manner, with approximately $IC_{50}$ of $70\;{\mu}g/mL$. These results suggest that delphinidin might be useful for cancer prevention.

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