Food Science and Biotechnology

  • 제16권4호
  • /
  • Pages.594-599
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  • 2007
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  • 1226-7708(pISSN)
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  • 2092-6456(eISSN)
한국식품과학회 (Korean Society of Food Science and Technology)
권호 표지

The Protective Effect of Chondroitin from Raja kenojei Cartilage on Collagen-induced Arthritis in DBA/1J Mice

  • Jin, Cheng-Hao (Department of Oral Biochemistry and Dental Science Institute, The 2nd Stage of Brain Korea 21 for Dental School, School of Dentistry, Chonnam National University) ;
  • Yang, Ung (School of Biological Sciences and Technology, Biotechnology Research Institute, Chonnam National University) ;
  • Kim, Song-Hee (School of Biological Sciences and Technology, Biotechnology Research Institute, Chonnam National University) ;
  • Ryu, Jae-Won (School of Biological Sciences and Technology, Biotechnology Research Institute, Chonnam National University) ;
  • Lee, Jae-Chang (Department of Dental Hygiene, Naju College) ;
  • Lee, Dong-Seok (Division of Animal Biotechnology, Animal Science Resources, Kangwon National University) ;
  • Lee, Tae-Hoon (Department of Oral Biochemistry and Dental Science Institute, The 2nd Stage of Brain Korea 21 for Dental School, School of Dentistry, Chonnam National University)
  • 발행 : 2007.08.31
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초록

In this study, we evaluated whether the oral administration of chondroitin from the cartilage of Raja kenojei is effective on the progression of rheumatoid arthritis (RA), using collagen-induced arthritic (CIA) mice. Arthritis development was delayed dose-dependently in the chondroitin-treated groups. The pre- and late-treated groups receiving 1,000 mg/kg of chondroitin had clinical scores that were reduced significantly by 56.9 (p<0.05) and 43.3% (p<0.05), respectively, compared to the vehicle-treated groups. Hematoxylin eosin staining and X-ray radiography showed that the chondroitins reduced the infiltration of inflammatory cells and prevented joint destruction of the knee and paw. Reverse transcription-polyerase chain reaction analysis revealed that chondroitin administration inhibited the expressions of tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$), $interlukin-1{\beta}$ ($IL-1{\beta}$), and $interferon-{\gamma}$ ($IFN-{\gamma}$) in joints more than the administration of vehicle. Chondroitin treatment also decreased the production of rheumatoid factors (RF), IgG and IgM, in the serum of CIA mice. These results indicate that chrondroitin administration has a protective effect involving the inhibition of pro-inflammatory cytokine production in CIA mice.

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