대한의생명과학회지 (Biomedical Science Letters)
- 제13권3호
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- Pages.239-244
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- 2007
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
A Homeotic Gene, Hoxc8, Regulates the Expression of Proliferating Cell Nuclear Antigen in NIH3T3 Cell
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- 김명희 (연세대학교 의과대학 해부학교실)
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Min, Hye-Hyun
(Department of Anatomy, Embryology Lab., Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine) ;
- Kang, Myeng-Mo (Department of Anatomy, Embryology Lab., Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine) ;
- Kim, Myoung-Hee (Department of Anatomy, Embryology Lab., Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine)
- 발행 : 2007.09.30
초록
Hoxc8 is one of the homeotic developmental control genes regulating the expression of many downstream target genes, through which animal body pattern is established during embryonic development. In previous proteomics analysis, proliferating cell nuclear antigen (PCNA) which is also known as cyclin, has been implied to be regulated by Hoxc8 in F9 murine embryonic teratocarcinoma cell. When the 5' upstream region of PCNA was analyzed, it turned out to contain 20 Hox core binding sites (ATTA) in about 1.17 kbp (kilo base pairs) region (