Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
권호 표지
DOI QR코드

DOI QR Code

Influence of Ointment Base on In Vitro Release Characteristics of Oregonin

오레고닌의 in vitro 방출 특성에 미치는 연고기제의 영향

  • Published : 2007.08.21
Download PDF
⟨ Previous Next ⟩

Abstract

The bark of Alnus japonica has been used for the treatment of fever, hemorrhage and diarrehea in oriental traditional medicine. Recently, it was revealed that the diarylheptanoids from the bark of Alnus japonica possess anti-inflammatory activity and are expected to be applicable for atopic dermatitis. In this study, oregonin, one of major active components in the bark of Alnus japonica, was developed in the form of semisolid formulations for topical delivery. Oregonin was incorporated into four ointment bases: O/W cream, W/O cream, hydrophilic ointment and lipophilic ointment. Oregonin release from all formulation prepared was evaluated. Franz cell method and immersion method were employed to characterize the release patterns of drug from each formulation based on solvent availability. O/W cream showed a better release profile than the other formulations when evaluated with Franz cell method with an order of O/W cream, hydrophilic ointment, W/O cream and lipophilic ointment. In the immersion method, hydrophilic ointment showed the greatest release rate at times 1 hour exceeding compared to other bases with an order of hydrophilic ointment, O/W cream, W/O cream and lipophilic ointment. Hydrophilicity and solvent availability of formulation seems to significantly influence the release rate of oregonin from ointment bases. In this study, we successfully characterized the oregon in ointment and found that o/w cream is a promising formulation for the topical delivery of oregonin.

Keywords

References

  1. 中藥大辭典(3권), p. 3042 小學館, 東京, (1985)
  2. S. J. Lee, Korean Folk Medicine, 서울, 40, (1966)
  3. M. W. Lee, M. S. Park, D. W. Jeong, K. H. Kim, H. H. Kim and S. H. Toh, Diarylheptanoids from the leaves of Alnus hirsuta Turcz, Arch. Pharm. Res., 23, 50-53 (2000) https://doi.org/10.1007/BF02976466
  4. D. W. Jeong, J. S. Kim, S. M. Cho, Y. A. Lee, K. H. Kim, S. W. Kim and M. W. Lww, Diarylheptanoids from the stem barks of Alnus hirsuta var. sibirica, Kor. J. Phamacog., 31, 28-33 (2000)
  5. M. W. Lee, D. W. Jeong, Y. A. Lee, M. S. Park, D. W. Jeong and S. H. Toh, Flavonoids from the leave of Alnus hirsua, Yakhak Hoeji., 43, 547-552 (1999)
  6. K. W. Ahn, S. H. Toh, D. W. Jeong, J. S. Kim, S. M. Cho and M. W. Lee, Flavonoids from the leave of Alnus maximowiczii Call, Yakhak Hoeji., 44, 41-46 (2000)
  7. M. W. Lee, T. Tanaka, G. Nonaka and I. Nishioka, Hirsunin, an ellagitannin with a diarylheptanoid moiety from Alnus hirsuta var. microphylla, Phytochemistry., 31, 967-970 (1992) https://doi.org/10.1016/0031-9422(92)80049-K
  8. M. W. Lee, T. Tanaka, G. I. Nonaka and I. Nishioka, Dimeric ellagitannins from Alnus japonica, Phytochemistry.. 31, 2835-2839 (1992) https://doi.org/10.1016/0031-9422(92)83642-C
  9. M. W. Lee, N. Y. Kim, M. S. Park, K. H. Ahn, S. H. Toh, D. R. Hahn, Y. C. Kim and H. T. Chung, Diarylheptanoids with In vitro Inducible Nitric Oxide Synthesis Inhibitory Activity from Alnus hirsuta, Planta Med., 66(6), 551-553 (2000) https://doi.org/10.1055/s-2000-8606
  10. M. W. Lee, J. H. Kim, D. W. Jeong, K. H. Ahn, S. H. Toh and Y. J. Surh, Inhibition of Cyclooxygenase-2 Expression by Diarylheptanoids from the Bark of Alnus hirsuta var. sibirica Biol, Pharm. Bull., 23(4), 517-518 (2000) https://doi.org/10.1248/bpb.23.517
  11. D. I. Lee, J. K. Chang, M. W. Lee and S. G. Hong, Effects of Oregonin, diarylheptanoid derivative from plant on antitumor, Chung-Ang J Pharm. Sci., 12, 50 (1998)
  12. Y. A. Lee, K. H. Kim, J. S. Kim, S. M. Cho, S. W. Kim and M. W. Lee, Antioxidative Effects of Darylheptanoids from Alnus hirsuta, Yakhak Hoeji., 44, 193-196 (2000)
  13. R. Yamazaki, H. Hatano, R. Aiyama, T. Matsuzaki, S. Hashimoto, T. Yokokura, Diarylheptanoids suppress expression of leukocyte adhesion molecules on human vascular endothelial cells, Eur. J. Pharm., 404(3), 375-385 (2000) https://doi.org/10.1016/S0014-2999(00)00620-8
  14. J. Hadgraft, Percutaneous absorption: possibilities and problems, Int. J Pharm., 16, 255-270 (1983) https://doi.org/10.1016/0378-5173(83)90145-X
  15. R. Neubert, W. Wohlrab, In vitro methods for biopharmaceutical evaluation of topical formulation, Acta. Pharm. Technol., 36, 197-206 (1990)
  16. I. Eros, Optimization of drug release from dermatological semisolid preparations, Drug Dev. Res., 59, 316-325 (2003) https://doi.org/10.1002/ddr.10213
  17. E. W. Park, Drug release and skin Irritancy of hydrogel and cream preparations containing kojic acid, 약제학회지, 28(3), 177-183 (1998)