The Journal of Korean Physical Therapy

  • 제19권1호
  • /
  • Pages.57-66
  • /
  • 2007
  • /
  • 1229-0475(pISSN)
  • /
  • 2287-156X(eISSN)
대한물리치료학회 (The Korean Society of Physical Therapy)
권호 표지

흰쥐의 제 2형 콜라겐 유도 관절염에 대한 우슬과 족삼리 전침 자극의 치료 효과

Therapeutic Effects of Achyrantes Radix and Electroacupuncture of Zusanli acupoint(ST36) on Type II Collagen-Induced Arthritis

  • 이재춘 (군장대학 물리치료과) ;
  • 오명화 (동신대학교 보건복지대학) ;
  • 남기원 (동신대학교 보건복지대학) ;
  • 김용억 (동신대학교 보건복지대학) ;
  • 유영대 (원광대학교 광주한방병원) ;
  • 장미경 (동강대학 다이어트 건강관리과) ;
  • 김계엽 (동신대학교 보건복지대학)
  • Lee, Jae-Choon (Department of Physical Therapy, Kunjang College) ;
  • Oh, Myung-Hwa (Department of Health and Welfare, Dongshin University) ;
  • Nam, Ki-Won (Department of Health and Welfare, Dongshin University) ;
  • Kim, Young-Eok (Department of Health and Welfare, Dongshin University) ;
  • Yoo, Young-Dae (Department of rehabilitation medicine, Wonkwang University Medical Center) ;
  • Chang, Mee-Kyung (Department of Diet & Health Management, Dongkang College) ;
  • Kim, Gye-Yeop (Department of Health and Welfare, Dongshin University)
  • 발행 : 2007.02.25
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초록

Purpose: We investigated the effects of the combined therapy in rats with rheumatoid arthritis induced by type II collagen for 28 days, which consisted of the oral administration of the AR and EA applied to zusanli acupoint(ST36). Methods: Normal group was oral administered with 0.9% NaCl $0.5\;m{\ell}/day$ to normal rats. Control group was oral administered with 0.9% NaCl $0.5\;m{\ell}/day$ to arthritic rats. Group I was oral administered with AR 500 mg/kg $0.5\;m{\ell}/day$ to arthritic rats. Group II was given 2 Hz EA of ST36 in the test group for 30 min/day to arthritic rats. Group III was oral administered with AR 500 mg/kg $0.5\;m{\ell}/day$ and 2 Hz EA of ST36 in the test group for 30 min/day to arthritic rats. We Observed effect of the histopathological changes by H&E stain of liver, kidney, knee joint and ELSIA of cytokines($TNF-{\alpha}$). Results: 1. The vacuolization of liver tissue was decreased in group I, II, III comparing with control group. 2. The glomerular sclerosis of kidney tissue was decreased in group I, II, III comparing with control group. 3. The erosion of arthritic site of knee joint tissue was decreased group I, II, III comparing with control group. In particular group III was the most effective comparing with group I, II on the histopathological view. 4. In the ELSIA test of $TNF-{\alpha}$ concentration, Control group significantly increased in the concentration more than group I, II, III. The rate of increase in concentration slowed down in group III more than group I, II(p<0.05). Conclusion: It is concluded that 500 mg/kg of AR extracts and EA have clear therapeutic effect on the rheumatoid arthritis.

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