Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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Seroprevalence of Brucellosis among Risk Population in Gyeongsangbuk-do, 2006

경상북도 거주 고위험군에서 브루셀라 감염에 관한 혈청 역학적 연구

  • Lee, Kwan (Department of Preventive Medicine, Dongguk University College of Medicine) ;
  • Park, Woo-Won (Gyeongsangbuk-do Institute of Health and Environment) ;
  • Kim, Sung-Hwan (Gyeongsangbuk-do Institute of Health and Environment) ;
  • Lee, Do-Young (Gyeongsangbuk-do Institute of Health and Environment) ;
  • Park, Mi-Yeoun (Division of Zoonoses, Korea National Institute of Health) ;
  • Hur, Young-Ju (Division of Epidemic Intelligence Service, Korea Center for Disease Control and Prevention) ;
  • Lim, Hyun-Sul (Department of Preventive Medicine, Dongguk University College of Medicine)
  • 이관 (동국의대 예방의학교실) ;
  • 박우원 (경상북도 보건환경연구원) ;
  • 김성환 (경상북도 보건환경연구원) ;
  • 이도영 (경상북도 보건환경연구원) ;
  • 박미연 (국립보건연구원 인수공통감염팀) ;
  • 허영주 (질병관리본부 역학조사팀) ;
  • 임현술 (동국의대 예방의학교실)
  • Published : 2007.07.31
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Abstract

Objectives : Cases of human brucellosis in Korea have recently increased due to the increasing incidence of bovine brucellosis. The authors conducted this study to elucidate the status of brucellosis through seroepidemiologic study. Methods : We selected our study population from a high risk group. We conducted a questionnaire survey and obtained blood samples to determine the seroprevalence of brucellosis antibodies for 10 days in February, 2005. The titers of brucellosis were measured by the combination of standard tube agglutination test (STA) and enzyme-linked immunosorbent assay (ELISA) test. Results : Our study subjects comprised 1,075 cases: 971 livestock workers, 51 veterinarians, and 53 artificial inseminators. In the STA test, 27 cases (2.5%) had titers of greater than or equal to 1:20. Of 1,068 cases (7 cases were excluded due to previous brucellosis), 7 cases of brucellosis were diagnosed with titers of 1:160, giving a seroprevalence of brucellosis of 0.66%. The seroprevalence in the male group was 0.95%, and that of livestock workers, veterinarians, and artificial inseminators was 0.52%, 4.17%, and 0.00%, respectively. The Spearman's correlation coefficient between the positive rate of bovine brucellosis per capita and household and human brucellosis was 0.806 and 0.744, respectively. The concordance rate between the Korea National Institute of Health and the Gyeongsangbuk-do Institute of Health and Environment by the STA and ELISA tests was 94.7% and 100.0%, respectively. Conclusions : The study results indicated in higher seroprevalence rate among veterinarians than among livestock workers and artificial inseminators. Because veterinarians may be exposed to this high risk, effective working guidelines for veterinarians to guard against brucellosis must be developed. Moreover, more extensive epidemiologic research for laboratory workers and meat handlers is needed.

Keywords

References

  1. Korea National Institute of Health. The amendment of the Korean infectious disease prevention Act. CDMR 2000; 11(2): 17 (Korean)
  2. Corbel MJ. Brucellosis-an overview. Emerg Infect Dis 1997; 3(2): 213-221 https://doi.org/10.3201/eid0302.970219
  3. Bravo MJ, de Dios Colmenero J, Alonso A, Caballero A. Polymorphisms of the interferon gamma and interleukin 10 genes in human brucellosis. Eur J Immunogenet 2003; 30(6): 433-435 https://doi.org/10.1111/j.1365-2370.2003.00419.x
  4. Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV. The new global map of human brucellosis. Lancet Infect Dis 2006; 6(2): 91-99 https://doi.org/10.1016/S1473-3099(06)70382-6
  5. Sauret JM, Vilissova N. Human brucellosis. J Am Board Fam Pract 2002; 15(5): 401-416
  6. Doganay M, Aygen B. Human brucellosis: An overview. Int J Infect Dis 2003; 7(3): 173-178 https://doi.org/10.1016/S1201-9712(03)90049-X
  7. Choi CS. Zoonoses. Seoul: Seohong publisher; 2002. p. 82-86 (Korean)
  8. Korea Center for Disease Control and Prevention. Current situation of human brucellosis. CDMR 2006; 17(2): 1-7 (Korean)
  9. Kim JS. The status of health and disease in Korean. Seoul: Shinkwang publisher; 2001. p. 319-322 (Korean)
  10. Kim SY, Kim JH, Hong HP, Lee SE, Cho KH, Lee YS. Strategies for Prevention and Seroprevalence of Bovine Brucellosis in Gyeonguk, 2005. In: Gyeongbuk Veterinary Service Laboratory. Report of Veterinary Service Laboratory. 2006. p. 75-86 (Korean)
  11. Lim HS, Lee K, Lee DY, Kim SH, Park WW. A Study on Preliminary Survey and the Development of Epidemiologic Investigation for the Human Brucellosis. Final report; 2006 (Korean)
  12. Lim HS, Min YS, Lee HS. Investigation of a series of brucellosis cases in gyeangsangbukdo during 2003-2004. J Prev Med Public Health 2005; 38(4): 482-488 (Korean)
  13. Sohn JY, Lee KU, Yoo JC, Park MS, Park KS, Lee IT, Kim BH, Kim YJ, Ko KS, Park HJ. Studies on zoonosis brucellosis. Report of NIH Korea 1986; 23: 281-295 (Korean)
  14. Lee YW, Lee KU, Lee SM, Park MS, Park KS, Lee MS, Park KW, Byun HS. Studies on bacteriological and serological diagnosis of human brucellosis. Report of NIH Korea 1988; 25: 257-266 (Korean)
  15. Yeom JS, Jung HC, Nam JH, Choi YH, Song YG, Kim E, Kim HS, Suh I, Kim JM. Seroepidemiologic study of brucellosis in Cheju Island. Korean J Infect Dis 1998; 30(2): 165-172 (Korean) https://doi.org/10.1080/003655498750003564
  16. Korea Centers for Disease Control and Prevention. Prevention and Control for Brucellosis. Seoul: Korea Centers for Disease Control and Prevention; 2003. p. 14-23 (Korean)
  17. Alsubaie S, Almuneef M, Alshaalan M, Balkhy H, Albanyan E, Alola S, Alotaibi B, Memish ZA. Acute brucellosis in Saudi families: relationship between brucella serology and clinical symptoms. Int J Infect Dis 2005; 9(4): 218-224 https://doi.org/10.1016/j.ijid.2004.07.009
  18. Abramson O, Rosenvasser Z, Block C, Dagan R. Detection and treatment of brucellosis by screening a population at risk. Pediatr Infect Dis J 1991; 10(6): 434-438 https://doi.org/10.1097/00006454-199106000-00003
  19. Abo-Shehada MN, Odeh JS, Abu-Essud M, Abuharfeil N. Seroprevalence of brucellosis among high risk people in northern Jordan. Int J Epidemiol 1996 ; 25(2): 450-454 https://doi.org/10.1093/ije/25.2.450
  20. Cetinkaya Z, Aktepe OC, Ciftci IH, Demirel R. Seroprevalence of human brucellosis in a rural area of Western Anatolia, Turkey. J Health Popul Nutr 2005; 23(2): 137-141
  21. Ajay Kumar VJ, Nanu E. Sero-positivity of brucellosis in human beings. Indian J Public Health 2005; 49(1): 22-24
  22. Hussein AA, Sayed AS, El Feki MA. Seroepidemiological study on human brucellosis in Assiut Governorate. Egypt J Immunol 2005; 12(1): 49-56
  23. Korea Centers for Disease Control and Prevention, Korea National Institute for Health. Guidelines for Laboratory Diagnosis of Statutory Communicable Diseases I. Seoul: Korea Centers for Disease Control and Prevention, Korea National Institute for Health; 2005. p. 152-159 (Korean)
  24. CDC. Case definitions for infectious conditions under public health surveillance. Centers for disease control and prevention. MMWR Recomm Rep 1997; 46(RR-10): 1-55
  25. Morata P, Queipo-Ortuno MI, Reguera JM, Garcia-Ordonez MA, Cardenas A, Colmenero JD. Development and evaluation of a PCRenzyme- linked immunosorbent assay for diagnosis of human brucellosis. J Clin Microbiol 2003; 41(1): 144-148 https://doi.org/10.1128/JCM.41.1.144-148.2003
  26. Nielsen K. Diagnosis of brucellosis by serology. Vet Microbiol 2002; 90(1-4): 447-459 https://doi.org/10.1016/S0378-1135(02)00229-8
  27. Nimri LF. Diagnosis of recent and relapsed cases of human brucellosis by PCR assay. BMC Infect Dis 2003; 3: 5 https://doi.org/10.1186/1471-2334-3-5
  28. Potasman I, Even L, Banai M, Cohen E, Angel D, Jaffe M. Brucellosis: An unusual diagnosis for a seronegative patient with abscesses, osteomyelitis, and ulcerative colitis. Rev Infect Dis 1991; 13(6): 1039-1042 https://doi.org/10.1093/clinids/13.6.1039
  29. Yang SY, Chung CK. Brucellar spondylodiscitis: Case report and literature review. J Korean Neurosurg Soc 2004; 35(3): 332-335 (Korean)