Seroprevalence of Brucellosis among Risk Population in Gyeongsangbuk-do, 2006

경상북도 거주 고위험군에서 브루셀라 감염에 관한 혈청 역학적 연구

  • Lee, Kwan (Department of Preventive Medicine, Dongguk University College of Medicine) ;
  • Park, Woo-Won (Gyeongsangbuk-do Institute of Health and Environment) ;
  • Kim, Sung-Hwan (Gyeongsangbuk-do Institute of Health and Environment) ;
  • Lee, Do-Young (Gyeongsangbuk-do Institute of Health and Environment) ;
  • Park, Mi-Yeoun (Division of Zoonoses, Korea National Institute of Health) ;
  • Hur, Young-Ju (Division of Epidemic Intelligence Service, Korea Center for Disease Control and Prevention) ;
  • Lim, Hyun-Sul (Department of Preventive Medicine, Dongguk University College of Medicine)
  • 이관 (동국의대 예방의학교실) ;
  • 박우원 (경상북도 보건환경연구원) ;
  • 김성환 (경상북도 보건환경연구원) ;
  • 이도영 (경상북도 보건환경연구원) ;
  • 박미연 (국립보건연구원 인수공통감염팀) ;
  • 허영주 (질병관리본부 역학조사팀) ;
  • 임현술 (동국의대 예방의학교실)
  • Published : 2007.07.31

Abstract

Objectives : Cases of human brucellosis in Korea have recently increased due to the increasing incidence of bovine brucellosis. The authors conducted this study to elucidate the status of brucellosis through seroepidemiologic study. Methods : We selected our study population from a high risk group. We conducted a questionnaire survey and obtained blood samples to determine the seroprevalence of brucellosis antibodies for 10 days in February, 2005. The titers of brucellosis were measured by the combination of standard tube agglutination test (STA) and enzyme-linked immunosorbent assay (ELISA) test. Results : Our study subjects comprised 1,075 cases: 971 livestock workers, 51 veterinarians, and 53 artificial inseminators. In the STA test, 27 cases (2.5%) had titers of greater than or equal to 1:20. Of 1,068 cases (7 cases were excluded due to previous brucellosis), 7 cases of brucellosis were diagnosed with titers of 1:160, giving a seroprevalence of brucellosis of 0.66%. The seroprevalence in the male group was 0.95%, and that of livestock workers, veterinarians, and artificial inseminators was 0.52%, 4.17%, and 0.00%, respectively. The Spearman's correlation coefficient between the positive rate of bovine brucellosis per capita and household and human brucellosis was 0.806 and 0.744, respectively. The concordance rate between the Korea National Institute of Health and the Gyeongsangbuk-do Institute of Health and Environment by the STA and ELISA tests was 94.7% and 100.0%, respectively. Conclusions : The study results indicated in higher seroprevalence rate among veterinarians than among livestock workers and artificial inseminators. Because veterinarians may be exposed to this high risk, effective working guidelines for veterinarians to guard against brucellosis must be developed. Moreover, more extensive epidemiologic research for laboratory workers and meat handlers is needed.

Keywords

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