임상약리학회지 (Journal of Korean Society for Clinical Pharmacology and Therapeutics)
- 제15권2호
- /
- Pages.99-106
- /
- 2007
- /
- 1225-5467(pISSN)
리팜피신 제제인 리팜핀정의 리포덱스정에 대한 생물학적동등성
Bioequivalence study of $Rifampin^{(R)}$ Tablet to $Rifodex^{(R)}$ Tablet(Rifampicin 600mg)
- 한승훈 (가톨릭대학교 의과대학/강남성모병원 임상약리학과) ;
- 홍은경 (가톨릭대학교 의과대학/강남성모병원 임상약리학과) ;
- 안병진 (가톨릭대학교 의과대학/강남성모병원 임상약리학과) ;
- 채홍석 (가톨릭대학교 의과대학/강남성모병원 임상약리학과) ;
-
임동석
(가톨릭대학교 의과대학/강남성모병원 임상약리학과)
- Han, Seung-Hoon (Department of Clinical Pharmacology and Therapeutics, The Catholic University of Korea, Kangnam St. Mary's Hospital) ;
- Hong, Eun-Kyung (Department of Clinical Pharmacology and Therapeutics, The Catholic University of Korea, Kangnam St. Mary's Hospital) ;
- Ahn, Byung-Jin (Department of Clinical Pharmacology and Therapeutics, The Catholic University of Korea, Kangnam St. Mary's Hospital) ;
- Chae, Hong-Seok (Department of Clinical Pharmacology and Therapeutics, The Catholic University of Korea, Kangnam St. Mary's Hospital) ;
-
Yim, Dong-Seok
(Department of Clinical Pharmacology and Therapeutics, The Catholic University of Korea, Kangnam St. Mary's Hospital)
- 발행 : 2007.12.01
초록
Background: Rifampicin is commonly used antimycobacterial drug and various formulations are available. The purpose of this study is to evaluate the bioequivalence of rifampicin in healthy Korean subjects. Methods: Under two way crossover Latin square design (2 sequences, 2 periods), twenty-one subjects were randomly allocated into two groups. After administration of rifampicin 600mg, blood sampling was done at prescheduled time points. Samples were analyzed using HPLC/UV method. Using WinNonlin V5.2,