대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제28권4호
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- Pages.902-910
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- 2007
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- 1226-9174(pISSN)
제 2형 당뇨병 및 당뇨 합병증의 발생과 Peroxisome Proliferator-Activated Receptor-$\gamma2$ C161T 유전자 다형성과의 관계
The Association between Peroxisome Proliferator-Activated Receptor-Gamma C161T Polymorphism and Type 2 Diabetic Complications
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이병철
(경희대학교 한의과대학 신계내과학교실) ;
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안세영
(경희대학교 한의과대학 신계내과학교실) ;
- 두호경 (경희대학교 한의과대학 신계내과학교실) ;
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안영민
(경희대학교 한의과대학 신계내과학교실)
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Lee, Byung-Cheol
(Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University) ;
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Ahn, Se-Young
(Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University) ;
- Doo, Ho-Kyung (Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University) ;
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Ahn, Young-Min
(Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University)
- 발행 : 2007.12.30
초록
Objective : Peroxisome proliferator-activated receptor (PPAR)-gamma, a transcription factor in adipocyte differentiation, has important effects on insulin sensitivity, atherosclerosis, endothelial cell function and inflammation. Through these effects, PPAR-gamma2 might be involved with type 2 diabetes and vascular disease, including diabetic complications. Recently, it has been reported that the C161T polymorphism in the exon 6 of PPAR-gamma is associated with type 2 diabetes interacting with uncoupling protein 2 (UCP2) gene, and is associated with acute myocardial infarction. We studied the association of this polymorphism with type 2 diabetes and its complications, such as retinopathy, ischemic stroke, nephropathy and neuropathy in Korean non-diabetic and type 2 diabetic populations. Methods : Three hundred and thirty eight type 2 diabetic patients (retinopathy: 64, ischemic stroke: 67, nephropathy: 39 and neuropathy: 76) and 152 healthy matched control subjects were evaluated. The PPAR-gamma C161T polymorphism was analyzed by PCR-RFLP. Results : PPAR-gamma C161T genotype and allele frequency did not show significant differences between type 2 diabetic patients and healthy controls (T allele: 17.0 vs. 14.5, OR= 1.21, P=0.3188). In the analysis for diabetic complications, T allele in diabetic nephropathy was significantly higher than controls (P=0.0358). T allele in the ischemic stroke patients was also higher than healthy controls, although it had no significance (P=0.1375). Conclusions : These results suggest that the C161T polymorphism of the PPAR-gamma gene might be associated with diabetic nephropathy in type 2 diabetes.
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