대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

무증상 뇌경색의 위험요인에 대한 환자;대조군 연구

The Case-Control Study of Risk Factors of Silent Cerebral Infarction

  • 백혜기 (대전대학교부속한방병원 심계내과학교실) ;
  • 고미미 (한국한의학연구원 의료연구부) ;
  • 유병찬 (한국한의학연구원 의료연구부) ;
  • 방옥선 (한국한의학연구원 의료연구부) ;
  • 오영선 (대전대학교 혜화병원) ;
  • 김연진 (대전대학교 혜화병원) ;
  • 김정현 (대전대학교부속한방병원 심계내과학교실) ;
  • 김윤식 (대전대학교부속한방병원 심계내과학교실) ;
  • 설인찬 (대전대학교부속한방병원 심계내과학교실)
  • Baek, Hye-Ki (Dept. of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Ko, Mi-Mi (Dept. of Medical Research, Korea Institute of Oriental Medicine) ;
  • Yu, Byeong-Chan (Dept. of Medical Research, Korea Institute of Oriental Medicine) ;
  • Bang, Ok-Sun (Dept. of Medical Research, Korea Institute of Oriental Medicine) ;
  • Oh, Yeong-Seon (Hae-hwa Hospital, Daejeon University) ;
  • Kim, Yeon-Jin (Hae-hwa Hospital, Daejeon University) ;
  • Kim, Jung-Hyun (Dept. of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Kim, Yoon-Sik (Dept. of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Seol, In-Chan (Dept. of Internal Medicine, College of Oriental Medicine, Daejeon University)
  • 발행 : 2007.12.30
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초록

Background : Cerebrovascular disease is a major cause of death and disability in adults. Silent cerebral infarction (SCI) portends more severe cerebral infarction or may lead to insidious progressive brain damage resulting in vascular dementia. Known cardiovascular risk factors, such as arterial hypertension, diabetes mellitus, smoking, hyperlipidemia and ischemic heart disease may increase the risk of SCI. This study was designed to evaluate the risk factors of SCI in an apparently normal adult population. Methods : We divided 340 neurologically normal adults (mean age=59.90$\pm$8.30, men:women = 146:194) who underwent brain computed tomography (CT) or magnetic resonance imaging (MRI) at the Stroke Medical Center in Daejeon University Oriental Medicine Hospital in two groups, Silent inf. and Controls,and analyzed risk factors of SCI by interview, physical examination and blood test. Risk factors of SCI were assessed by interview, physical examination and blood test. We performed Pearson's chi-square test and two-sample t-test for univariate analysis and multiple logistic regressions for multivariate analysis to evaluate risk factors of SCI. Results : Old age, diabetes mellitus, and high lactate dehydrogenase (LDH) levels were associated with SCI on univariate analysis. Diabetes mellitus was demonstrated to be an independent risk factor for SCI on multivariate analysis. Conclusions : Advanced age, diabetes mellitus, and LDH levels are associated with SCI.

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