Journal of Haehwa Medicine (혜화의학회지)

Research Institute of Korean Medicine (대전대학교 한의학연구소)
권호 표지

Effect of Jeseupwiryeongtang-Kamibang(JWRTK) on atopic dermatitis-like skin lesions induced in NC/Nga mice by mite antigen stimulation

제습위령탕가미방(除濕胃笭湯加味方)이 NC/Nga mice의 아토피 발진 억제에 미치는 실험적 연구

  • Na, Dong-Kyu (Dept. of Pediatrics, College of Oriental Medicine, Dae-Jeon University) ;
  • Kim, Yun-Hee (Dept. of Pediatrics, College of Oriental Medicine, Dae-Jeon University) ;
  • Han, Jae-Kyung (Dept. of Pediatrics, College of Oriental Medicine, Dae-Jeon University) ;
  • Kim, Yun-Hee (Dept. of Pediatrics, College of Oriental Medicine, Dae-Jeon University)
  • 나동규 (대전대학교 한의과대학 소아과학교실) ;
  • 김윤희 (대전대학교 한의과대학 소아과학교실) ;
  • 한재경 (대전대학교 한의과대학 소아과학교실) ;
  • 김윤희 (대전대학교 한의과대학 소아과학교실)
  • Accepted : 2007.06.10
  • Published : 2007.06.30
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Abstract

Objective : We wished to examine closely effect that Kami-JeSeubUilYeongTang medicines used to atopy dermatitis disease patient get in atopy eruption control experimentally. Materials and Methods : Atopic dermatitis (AD) usually develops in patients with an individual or family history of allergic diseases, and is characterized by chronic relapsing inflammation seen specially in childhood, association with IgE hyperproduction and precipitation by environmental factors. However, the exact etiology of AD has been unclear. To further explore the pathogenesis and treatment of AD, a suitable animal model is required. We found that skin lesions, which were clinically and histologically very similar to human AD, mite antigen-induced dermatitis on the face, neck, ears and dorsal skin of inbred NC/Nga mice. Result and Conclusion : Kami-jeseupwiryeongtang(JWRTK) medicines controlled CD3+/CD69+, CD4+/CD25+, B220+/IgE+, and B220+/CD23+ revelation that an experiment that motive allergy immune reponse because an in vitro experiment stimulates splenocytes of a NC/Nga mouse same time by PWM, and interleukin-4, eotaxin 2, CCR3, TARC mRNA outturn that bear in splenocytes decreased remarkably by Jeseupwiryeongtang-Kamibang(JWRTK) medicines. Th1 cell and Th2 cell observe to be shifted by secretion amount of IL-4 and IFN-$\gamma$ by Jeseupwiryeongtang-Kamibang(JWRTK) medicines could know that Jeseupwiryeongtang-Kamibang(JWRTK) medicines can use usefully in allergy autoimmnune diease.

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