Journal of Haehwa Medicine (혜화의학회지)

Research Institute of Korean Medicine (대전대학교 한의학연구소)
권호 표지

Anti-aging and Anti-Oxidative Effect of SYG (SipYiMiGwanJungTang) in aged Rats

십이미관중탕(十二味寬中湯)의 노화(老化) 억제 효과에 대한 실험적(實驗的) 연구(硏究)

  • Sun, Teh-Cheng (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Daejeon University) ;
  • Anh, Taek-Won (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Daejeon University)
  • 손덕칭 (대전대학교 한의과대학 사상체질의학교실) ;
  • 안택원 (대전대학교 한의과대학 사상체질의학교실)
  • Accepted : 2007.12.14
  • Published : 2007.12.31
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Abstract

The purpose of this study is to investigate the anti-aging and anti-oxidative effects of oral administration with SYG (SipYiMiGwanJungTang) decoction in early aged rats. The results were as follows : 1. At the 52 week of the SYG group, the body weight gain was decreased. 2. At the 52 week of the SYG group, the activity of the SOD in the liver was significantly increased than the 10, 22 and 40 week. 3. At the 52 week of the SYG group, the level of the glutathione in the liver was significantly increased than the normal group. 4. At the 68 week of the SYG group, the activity of the catalase in the liver was significantly increased than the normal and control group. 5. At the 52 week of the normal group, the level of the NO in the liver was significantly increased than the 22 and 40 weeks. But, the level of the NO of the SYG group was not changed by the aging. 6. At the 52 and 68 weeks of the SYG group, the level of the MDA in the liver was significantly decreased than the normal and control groups. These results suggest that oral administration of SYG (SipYiMiGwanJungTang) decoction has anti-oxidative and anti-aging effects in early aged rats.

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