Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
권호 표지

Effects of Personal Exposure to Nitrogen Dioxide on Peak Expiratory Flow in Asthmatic Patients

이산화질소 개인 노출량이 기관지천식 환자의 최대호기유속에 미치는 영향

  • Kwon, Ho-Jang (Department of Preventive Medicine, Dankook University College of Medicine) ;
  • Lee, Sang-Gyu (Department of Preventive Medicine, Dankook University College of Medicine) ;
  • Jee, Young-Koo (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Lee, Sang-Rok (Cheongju St Mary's Hospital) ;
  • Hwang, Seung-Sik (National Cancer Center)
  • 권호장 (단국대학교 의과대학 예방의학교실) ;
  • 이상규 (단국대학교 의과대학 예방의학교실) ;
  • 지영구 (단국대학교 의과대학 내과학교실) ;
  • 이상록 (청주 성모병원 내과) ;
  • 황승식 (국립암센터)
  • Published : 2007.01.31
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Abstract

Objectives : Nitrogen dioxide $(NO_2)$ has been inconsistently associated with gradual decreases in lung function. Here, we studied the effects of $NO_2$ exposure in asthmatics by examining the association between changes in lung function and concentrations of $NO_2$ which were personally measured. Methods : Peak expiratory flow (PEF) and daily personal exposures to $NO_2$ were recorded on 28 patients with asthma (confirmed by methacholine provocation test) over 4 weeks. We used generalized estimating equations to assess the relationship between personal $NO_2$ exposure and PEF, adjusting for potential confounders such as age, gender, outdoor particulate matter, temperature, humidity, and exposure to environmental tobacco smoke. Results : The personal $NO_2$ exposures were higher than the corresponding ambient levels. The mean personal: ambient ratio for $NO_2$ was 1.48. The personal $NO_2$ exposures were not associated with the morning PEF, evening PEF, or the diurnal PEF variability. However, environmental tobacco smoke was negatively associated with both the morning and evening PEF. Conclusions : Among the asthmatic adults who participated in this study, we found no apparent impact of personal $NO_2$ exposures on the peak expiratory flow.

Keywords

References

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