Natural Product Sciences

  • 제13권2호
  • /
  • Pages.101-104
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  • 2007
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

Cytoprotective Activity of Belamcanda chinensis Rhizome Against Glutamate-Induced Oxidative Injury in HT22 Cells

  • Jeong, Gil-Saeng (X-ray Microscopy Research Center, Wonkwang University) ;
  • An, Ren-Bo (College of Pharmacy, Wonkwnag University, College of Pharmacy, Yanbian University) ;
  • Oh, Seung-Hwan (Central R&D Center, Kwang Dong Pharmaceutical Co.) ;
  • Kang, Dae-Gill (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Ho-Sub (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Youn-Chul (College of Pharmacy, Wonkwang University)
  • 발행 : 2007.06.30
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초록

Four isoflavones including tectorigenin (1), irisflorentin (2), irigenin (3), and tectoridin (4) have been isolated from the 70% EtOH extract of Belamcanda chinensis rhizome. The evaluation for protective effect of compounds 1-4 against glutamate-induced cytotoxicity in hippocampal HT22 cell line was conducted. Compound 1 showed significant protective effect with an EC$_{50}$ value of 67.25 ${\pm}$ 1.2 ${\mu}$M, whereas compounds 2-4 were inactive. These results suggest that compound 1 may possess the neuroprotective activity against oxidative cellular injures.

키워드

참고문헌

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