The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
권호 표지

The Experimental Study on anti-inflammatory Effects of Kagamsunbanghwalmyungeum(KSBH)

가감선방활명음(加減仙方活命飮)의 항염작용(抗炎作用)에 대한 실험적(實驗的) 연구(硏究)

  • Shin, Sun-Mi (Dept. of Oriental Medicine Graduate School, Daejeon University) ;
  • Kim, Soo-Min (Dept. of Oriental Medicine Graduate School, Daejeon University) ;
  • Kim, Eui-Il (Dept. of Oriental Medicine Graduate School, Daejeon University) ;
  • Lee, Jung-Eun (Dept. of Oriental Medicine Graduate School, Daejeon University) ;
  • Yoo, Dong-Youl (Dept. of Oriental Medicine Graduate School, Daejeon University)
  • 신선미 (대전대학교 한의과대학 부인과교실) ;
  • 김수민 (대전대학교 한의과대학 부인과교실) ;
  • 김의일 (대전대학교 한의과대학 부인과교실) ;
  • 이정은 (대전대학교 한의과대학 부인과교실) ;
  • 유동열 (대전대학교 한의과대학 부인과교실)
  • Published : 2007.02.28
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Abstract

Purpose : This study was to investigate the anti-inflammatory effects of Kagamsunbanghwalmyungeum(KSBH) which has been medicated the patient such as breast abscess. Methods : In the study of anti-inflammatory effects, KSBH was investigated using cultured cells and a murine models. As for the parameters of inflammation, level of several inflammatory cytokines and chemical mediators which are known to be related to inflammation were determined in mouse lung fibroblast cell(mLFC) and RAW 264.7 cells. Results : The cytotoxicity on mouse lung fibroblast cells(mLFC) was not served at all concentration of KSBH. KSBH in RAW264.7 cell inhibited IL-l${\beta}$, IL-6, TNF-${\alpha}$, COX-2 and NOS-II mRNA genes expression in a concentration-dependent manner, and specially inhibited NOS-II production very significantly at 100${\mu}$g/ ml. KSBH inhibited NO production significantly in a concentration-dependent manner and ROS production in a concentration-dependent manner. KSBH inhibited IL-l${\beta}$, IL-6 and TNF-${\alpha}$ production significantly in serum of acute anti-inflammation-induced mice. KSBH increased the survival rate from the 3rd day on LPS-induced lethal endotoxemia. Conclusion : These results suggest that Kagamsunbanghwalmyungeum(KSBH) can be useful in treating a lot of women mammary diseases caused by inflammation such as breast abscess.

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