생명과학회지 (Journal of Life Science)

한국생명과학회 (Korean Society of Life Science)
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B16/F10 생쥐 흑색종 세포에서 제주조릿대 추출물의 멜라닌 합성 저해 효과

The inhibitory effect on the melanin synthesis in B16/F10 mouse melanoma cells by Sasa quelpaertensis leaf extract

  • 윤훈석 (제주대학교 지역기술혁신센터 및 제주대학교 생명과학과, 고려대학교 생명과학과) ;
  • 김정국 (고려대학교 생명과학과) ;
  • 김세재 (제주대학교 지역기술혁신센터 및 제주대학교 생명과학과)
  • Yoon, Hoon-Seok (Technology innovation Center for Life Sciences and Department of Life Science, Cheju National University, Department of Life Sciences, School of Life Science and Biotechnology, Korea University) ;
  • Kim, Jeong-Kook (Department of Life Sciences, School of Life Science and Biotechnology, Korea University) ;
  • Kim, Se-Jae (Technology innovation Center for Life Sciences and Department of Life Science, Cheju National University)
  • 발행 : 2007.06.25
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초록

Effects of hot-water extract from Sasa quelpaertensis leaf (HWES) on melanogenesis were investigated in B16/F10 mouse melanoma cells. HWES inhibited cellular tyrosinase activity and melanin biosynthesis in a dose-dependent manner. Western blotting analysis showed that HWES dose-dependently inhibited tyrosinase and tyrosinase related protein-1 expression. Also, HWES suppressed sustained ERK activation in a concentration-dependent manner, suggesting that HWES inhibits the melanin biosynthesis through the suppressive effect against pathway involving sustained ERK activation.

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참고문헌

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