생명과학회지 (Journal of Life Science)

한국생명과학회 (Korean Society of Life Science)
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종양 항원의 발견: SEREX

SEREX; discovery of tumor antigens

  • 이상률 (부산대학교 의과대학 생화학 교실)
  • Lee, Sang-Yull (Department of Biochemistry, School of Medicine, Pusan national University)
  • 발행 : 2007.06.25
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⟨ 이전 논문 다음 논문 ⟩

초록

종양항원의 동정과 발견은 암 백신 및 진단개발에 매우 중요하다. 암환자의 혈청에서 종양 항원를 동정하는 SEREX가 개발되어왔다. SEREX에서 동정된 종양항원은 진단의 분자 지표 뿐 만 아니라 항암 백신 개발에 응용되고 있다. 따라서 SEREX는 종양항원 동정에 사용되어지는 매우 강력한 방법이다. 항암 백신의 개발은 동정된 종양항원이 체 또는 T cell에 기초하여 작동하는지 해명하는 것이 중요한 요소이다. 이 논문은 강력한 종양항원의 동정 방법인 SEREX 의 응용에 관하여 고찰 할 것이다.

The identification of tumor antigens is essential for the development of anticancer therapeutic vaccines and clinical diagnosis of cancer. SEREX (serological analysis of recombinant cDNA expression library)has been used to identify such tumor antigens by screening sera of cancer patients with cDNA ex-pression libraries. SEREX-defined antigens provide markers for the diagnosis of cancers. SEREX is also a powerful method for the development of anticancer therapeutics. The development of anticancer vaccines requires that tumor antigens can elicit antigen-specific antibodies or T lymphocytes. This re-view provides information on the application of SEREX for discovery of tumor antigens.

키워드

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피인용 문헌

  1. Review of Cancer-Testis (CT) Genes vol.21, pp.6, 2011, https://doi.org/10.5352/JLS.2011.21.6.912