Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Decoction and Powder of Sipjotang with Jujubae fructus or Licorice on Liver and Kidney

  • Seo, In-Gyo (College of Oriental Medicine, Daegu Haany University) ;
  • Zhao, Rong-Jie (College of Oriental Medicine, Daegu Haany University, College of Medicine, Yanbian University) ;
  • Park, Eun-Young (College of Oriental Medicine, Daegu Haany University, Development Team for The New Drug of Oriental Medicine (BK21 Program)) ;
  • Park, Sang-Mi (College of Oriental Medicine, Daegu Haany University, Development Team for The New Drug of Oriental Medicine (BK21 Program)) ;
  • Choi, Song-I (College of Oriental Medicine, Daegu Haany University) ;
  • Kim, Han-Kyun (College of Oriental Medicine, Daegu Haany University) ;
  • Park, Sook-Jahr (College of Oriental Medicine, Daegu Haany University, Development Team for The New Drug of Oriental Medicine (BK21 Program)) ;
  • Kwon, Young-Kyu (College of Oriental Medicine, Daegu Haany University, Development Team for The New Drug of Oriental Medicine (BK21 Program)) ;
  • Kim, Sang-Chan (College of Oriental Medicine, Daegu Haany University, Development Team for The New Drug of Oriental Medicine (BK21 Program))
  • Published : 2007.02.25
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Abstract

The effects of Jujubae Fructus and Licorice extracts on the main components of Sijotang Euphorbiae Kansui Radix, Daphinis Genkwa Flos, Euphonrbiae Pekinensis Radix (KWD) treatment [KWD decoction (KWDD) and KWD powder (KWDP)] related toxicities were examined in the kidney and the liver. To select more suitable extract which effectively reduce KWD-treatment related toxicities in the body, blood biochemical and histopathological changes induced by KWD were analyzed in the rats which received treament of KWD + Jujubae Fructus or KWD + Licorice. In the present study, no KWD-treatment related blood biochemical and histopathological change in the liver was detected. However, increase of tubules containing hyaline casts and atrophic tubules in the kidney was detected as the indicators of KWDD treatment related nephrotoxicity. Addition of Jujubae Fructus (KWDDJ) or Licorice (KWDDL) extracts effectively inhibited the nephrotoxcity induced by KWDD treatments. More ameliorated effects were acquired by addition of Jujubae Fructus extract (KWDDJ) than Licorice (KWDDL). In KWDP treatment, there was no significant difference in the number of tubules containing hyaline casts in all drug treated groups compared to normal or control group except for high dose of KWDP. Both of Jujubae Fructurs and Licorice reduced high dose of KWDP treatment related nephrotoxicity, and there was no significant difference between KWDPJs and KWDPLs. It is concluded that addition of Jujubae Fructus is more suitable than Licorice in reducing the nephrotoxicty of KWDD, also it is more suitable to taking Sipjotang in the form of powder than decoction.

Keywords

References

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