동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제21권1호
  • /
  • Pages.165-170
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  • 2007
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

평위산(平胃散) 약침액(藥鍼液)의 활성산소 및 활성질소 소거능

Scavenging Property of Pyungwi-san Herbal-acupuncture Solution on ROS and RNS

  • 이효승 (심혈관계질환 천연물개발연구센터 & 동국대학교 한의과대학 경혈학교실) ;
  • 문진영 (심혈관계질환 천연물개발연구센터 & 동국대학교 한의과대학 경혈학교실)
  • Lee, Hyo-Seung (Cardiovascular Medical Research Center and Department of AM-Pointology, College of Korean Medicine, Dongguk University) ;
  • Moon, Jin-Young (Cardiovascular Medical Research Center and Department of AM-Pointology, College of Korean Medicine, Dongguk University)
  • 발행 : 2007.02.25
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초록

Pyungwi-san(PWS) have been using as a basic prescription of digestive disorder in Korean traditional medicine. This study was performed to examine the in vitro antioxidant activity of the extract using different antioxidant tests including by 1,1-diphenyl-2-picryl-hydrazil (DPPH) radical scavenging, superoxide anion radical scavenging, metal chelating hydrogen peroxide scavenging, lipid peroxydation protective effect and scavenging effect of nitric oxide and peroxynitrite. Herbal-acupuncture solution of PWS(PWS-HS) exhibited a concentration-dependent inhibition of DPPH radical adduct formation and it showed dose-dependent free radical scavenging activity onto superoxide anions. In addition, the result of metal chelating hydrogen peroxide scavenging and ammonium thiocyanate experiments showed that PWS-HS was an active scavenger of hydroxyl radicals. Furthermore, it was also found to be effective in scavenging nitric oxide and peroxynitrite, well-known cytotoxic species that can oxidize several cellular components such as proteins, lipids and DNA.

키워드

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