Immunomodulating Activity of BL18 (Ganshu) Acupuncture on the Experimental Liver Metastasis Model of Mice

  • Kim, Myoung-Dong (Department of Physiology, College of Oriental Medicine, Sangji University) ;
  • Kim, Sung-Hoon (Department of Pathology, College of Oriental Medicine, Kyunghee University) ;
  • Lee, Soo-Jin (Department of Physiology, College of Oriental Medicine, Sangji University)
  • Published : 2007.06.25

Abstract

We investigated that the immunomodulating activity of BL18 (Ganshu) acupuncture on the experimental liver metastasis model of mice. NA (non-acupoint)- and BL18-treatment enhanced the mitogenic activity of BALB/c whole splenocytes induced by various mitogenic stimuli. Acupuncture treatment tended to increase splenocytes differentiation even though did not show significance. Acupuncture treatment caused a marked increase of production of Th1 cytokine (IFN-${\gamma}$) and Th2 cytokine (IL-4) by splenocytes and IL-12 and IFN-Y by macrophages. The increase of cytokine production on BL18-treated group was more pronounced compared to NA-treated group. The liver weight of NA- and BL18-treated group decreased compared to tumor group, but did not showed significant differences.

Keywords

References

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