Effect of Chungyeoldodam-tang on Hypertension

청열도담탕이 고혈압에 미치는 영향

  • Park, Kyung-Ho (Department of Pathology, College of Oriental Medicine, Deajeon University) ;
  • Choi, Hak-Joo (Department of Pathology, College of Oriental Medicine, Deajeon University) ;
  • Roh, Seong-Soo (Laboratory of Herbology, College of Oriental Medicine, Deajeon University) ;
  • Koo, Young-Sun (Department of Internal Medicine, College of Oriental Medicine, Deajeon University) ;
  • Kim, Dong-Hee (Department of Pathology, College of Oriental Medicine, Deajeon University)
  • 박경호 (대전대학교 한의과대학 병리학교실) ;
  • 최학주 (대전대학교 한의과대학 병리학교실) ;
  • 노성수 (대전대학교 한의과대학 본초학교실) ;
  • 구영선 (대전대학교 한의과대학 내과학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실)
  • Published : 2007.06.25

Abstract

To access the safety and efficacy of Chungyeoldodam-tang(CDT), a traditional herbal medicine prescription, on hypertension we examined various parameters involved in the pathogenesis of hypertension. CDT seems to be safe because CDT at the concentrations lower that 250 ug/ml showed no toxic effects in cultured human fibroblast and no toxic effects on liver function. The production of reactive oxygen species (ROS) were greatly decreased in CDT treated group compared with control, and angiotensin converting enzyme activities were reduced by CDT in a dose dependent manner. There was no differences in weight of hearts between control and CDT treated group. The blood pressure and pulse rate were significantly decreased. CDT greatly reduced the levels of plasma hormones including aldosterone, dopamine, and norepinephrine, but not epinephrine, and serum electrocytes including Na$^+$ and Cl$^-$, but not K$^+$. were also decreased. The levels of uric acid, BUN and creatinine were significantly decreased compared with control. These results suggested that CDT has suppressive effects on various pathologic factors in hypertension, and CDT has potential as a safe and effective therapeutics for hypertension.

Keywords

References

  1. Guido Grassi, Bianca M. Cattaneo, Gino Seravalle, Antonio Lanfranchi, and Giuseppe Mancia Baroreflex Control of Sympathetic Nerve Activity in Essential and Secondary Hypertension. Hypertension 31: 68-72, 1998 https://doi.org/10.1161/01.HYP.31.1.68
  2. Elliott, P., Stamler, J., Nichols, R., Dyer, A.R., Stamler, R., Kesteloot, H., Marmot, M. Intersalt revisited: further analyses of 24 hour sodium excretion and blood pressure within and across populations. Intersalt Cooperative Research Group. BMJ. 312(7041):1249-1253, 1996 https://doi.org/10.1136/bmj.312.7041.1249
  3. Yamori, Y., Nara, Y., Mizushima, S., Mano, M., Sawamura, M., Kihara, M., Horie, R. International cooperative study on the relationship between dietary factors and blood pressure: a report from the Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study. J Cardiovasc Pharmacol. 8: S43-47, 1990
  4. 손숙미 외. 한국인의 소금섭취 현황과 영양문제, 대한지역사회영양학회지 7(3):381-390, 2005
  5. Sharuta, J.S. 高血壓治療ガイドライン 2004. 日本高血壓學會 2004
  6. George Koike. Current and strategy for antihypertensive medication. Folica Pharmacol. Jpn, 127: 393-398, 2006 https://doi.org/10.1254/fpj.127.393
  7. Yoshihiko, S. Risk factors of Cardiovascular disease and those managements especially for acute coronary syndrome. J Nippon Med Sch. 67(3):202-205, 2000 https://doi.org/10.1272/jnms.67.202
  8. 심익현 외. 목향조기산 추출물이 국소 뇌혈류량 및 평균 혈압에 미치는 영향, 대한동의생리병리학회지 20(6):1538-1542, 2006
  9. 김천중 외. 죽력과 대나무 추출액의 혼합물이 뇌혈류 및 혈압에 미치는 영향, 대한동의생리병리학회지 20(6):1612-1619, 2006
  10. 정현우 외. 오가피 50% 에탄올 추출물이 면역, 항암, 뇌혈류 및 혈압에 미치는 영향, 대한동의생리병리학회지 19(5):1213-1220, 2006
  11. 서정철 외. 한국인과 중국인에서 고려삼과 화기삼의 혈압과 맥박에 대한 이중맹검 - 무작위 임상실험, 대한동의생리병리학회지 18(2):606-611, 2006
  12. 한덕희 외. 간양상항방이 고혈압에 미치는 영향, 대한동의생리병리학회지 20(3):663-669, 2006
  13. Hernandez, N., Torres, S.H., Finol, H.J., Sosa, A., Cierco, M. Capillary and muscle fiber type changes in DOCA-salt hypertensive rats. Anat Rec. 246(2):208-216, 1996 https://doi.org/10.1002/(SICI)1097-0185(199610)246:2<208::AID-AR7>3.0.CO;2-X
  14. Booth, R.E., Johnson, J.P., Stockand, J.D. Aldosterone. Adv Physiol Educ. 26: 8-20, 2002 https://doi.org/10.1152/advan.00051.2001
  15. Cushman, D.W., Cheung, H.S., Sabo, E.F., Ondetti, M.A. Development and design of specific inhibitors of angiotensin-converting enzyme. Am J Cardiol. 49(6):1390-1394, 1982 https://doi.org/10.1016/0002-9149(82)90348-4
  16. Odachi, J.K. Lifestyle-related disease and dietary education. Seikatsu eisei 50(5):372-377, 2006
  17. Connell, J.M., Davies, E. The new biology of aldosterone. J Endocrinol 186(1):1-20, 2005 https://doi.org/10.1677/joe.1.06017
  18. Rocha, R., Martin-Berger, C.L., Yang, P., Scherrer, R., Delyani, J., McMahon, E. Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart. Endocrinology 143(12):4828-4836, 2002 https://doi.org/10.1210/en.2002-220120
  19. Bradbury, D.A., Newton, R., Zhu, Y.M., Stocks, J., Corbett, L., Holland, E.D., Pang, L.H., Knox, A.J. Effect of bradykinin, TGF-beta1, IL-1beta, and hypoxia on COX-2 expression in pulmonary artery smooth muscle cells.Am J Physiol Lung Cell Mol Physiol. 283(4):L717-725, 2002 https://doi.org/10.1152/ajplung.00070.2002
  20. Goncalves, A.R., Fujihara, C.K., Mattar, A.L., Malheiros, D.M., Noronha Ide, L., de Nucci, G., Zatz, R. Renal expression of COX-2, ANG II, and AT1 receptor in remnant kidney: strong renoprotection by therapy with losartan and a nonsteroidal anti-inflammatory. Am J Physiol Renal Physiol. 286(5):F945-954, 2004 https://doi.org/10.1152/ajprenal.00238.2003
  21. 吉川公平. 高血壓治療藥の基礎: 開發中の高血壓治療藥. 日本藥理學會誌 127(381-386), 2006
  22. Dhawan, V., Jain, S. Effect of garlic supplementation on oxidized low density lipoproteins and lipid peroxidation in patients of essential hypertension. Mol Cell Biochem. 266(1-2):109-115, 2004 https://doi.org/10.1023/B:MCBI.0000049146.89059.53
  23. McCall, K.L., Craddock, D., Edwards, K. Effect of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers on the rate of new-onset diabetes mellitus: a review and pooled analysis. Pharmacotherapy 26(9):1297-1306, 2006 https://doi.org/10.1592/phco.26.9.1297
  24. Kelly, D.J., Zhang, Y., Cox, A.J., Gilbert, R.E. Combination therapy with tranilast and angiotensin-converting enzyme inhibition provides additional renoprotection in the remnant kidney model. Kidney Int. 69(11):1954-1960, 2006 https://doi.org/10.1038/sj.ki.5000376
  25. Rhaleb, N.E., Peng, H., Alfie, M.E., Shesely, E.G., Carretero, O.A. Effect of ACE inhibitor on DOCA-salt- and aortic coarctation-induced hypertension in mice: do kinin B2 receptors play a role? Hypertension. 33(1 Pt 2):329-334, 1999 https://doi.org/10.1161/01.HYP.33.1.329
  26. Booth, R.E., Johnson, J.P., Stockand, J.D. Aldosterone. Adv Physiol Educ. 26(1-4):8-20, 2002 https://doi.org/10.1152/advan.00051.2001
  27. Navar, L.G., Harrison-Bernard, L.M., Nishiyama, A., Kobori, H. Regulation of intrarenal angiotensin II in hypertension. Hypertension 39(2 Pt 2):316-322, 2002 https://doi.org/10.1161/hy0202.103821
  28. 고현철. KT2-962의 급성허혈성 신부전 유발 흰쥐에서의 혈중 요소질소 및 Creatinine 농도 상승에 미치는 영향. 한양대 대학원 1992
  29. Buss, S.J., Backs, J., Kreusser, M.M., Hardt, S.E., Maser-Gluth, C., Katus, H.A., Haass, M. Spironolactone preserves cardiac norepinephrine reuptake in salt-sensitive Dahl rats. Endocrinology 147(5):2526-2534, 2006 https://doi.org/10.1210/en.2005-1167
  30. Takase, B., Akima, T., Satomura, K., Ohsuzu, F., Mastui, T., Ishihara, M., Kurita, A. Effects of chronic sleep deprivation on autonomic activity by examining heart rate variability, plasma catecholamine, and intracellular magnesium levels. Biomed Pharmacother 1: S35-39, 2004
  31. Tan, L.B., Schlosshan, D., Barker, D. Fiftieth anniversary of aldosterone: from discovery to cardiovascular therapy. Int J Cardiol. 96(3):321-333, 2004 https://doi.org/10.1016/j.ijcard.2004.05.004
  32. 西山 成, 安部 陽一 腎障害とアルドステロン. 日本薬理学会誌 124: 101-109, 2004