Trans Fatty Acids of Breast Milk Lipids of Korean Women from Week 1 to 6 Months of Postpartum

한국인 모유의 수유단계별 트랜스지방산 함량

  • Kong, Kyeong-A (Department of Food and Nutrition, Chonnam National University) ;
  • Lim, Hyeon-Sook (Human Ecology Research Institute, Chonnam National University)
  • 공경아 (전남대학교 생활과학대학 식품영양학과) ;
  • 임현숙 (전남대학교 생활과학연구소)
  • Published : 2007.06.30

Abstract

This study was done to determine the trans fatty acid (tFA) composition of human milk from postpartum to sixth months after delivery, to investigate the tFA intake of lactating women, and to estimate the intakes of tFA by infants exclusively fed breast milk. A total of 27 lactating Korean women participated to this study voluntarily, gave their breast milk, and responded to an investigation of their diets. The lactating women consumed 2.3-2.8 g/d of tFAs over the period of the first, second, third, and sixth months postpartum, which was 3.4-4.9% of the total fat intake and 0.8%-1.2% of the total energy intake. The proportions of tFAs in the breast milk were 1.89% in colostrum, 1.78% in transitional milk, and 1.78-2.25 in mature milk of the first, second, third, and sixth months postpartum. The tFAs of the breast milk identified in this study were C16:1n9t, C18:1n9t, C18:2n6t12t, C18:2n6t12c, C18:2n6t12t and C18:2n6t11t. Among them, C18:1n9t was predominant, which made up 59.26% of all tFAs in cob strum, 62.36% in transitional milk, and 64.42% in mature milk. The proportion of total tFA was unchanged with time, although some significant differences were noted for individual tFAs. The percentages of C18:2n6t12c and C18:2n6c12t decreased over the study period. Estimated tFA intake of the exclusively breast-fed infants was 0.18 g/d when fed colostrum, 0.29 g/d when fed transitional milk, and 0.53 g/d when fed mature milk until the sixth month of postpartum. Those were 0.5%, 0.8%, and 1.1% of the total energy intake. The results in this study indicate that lactating Korean women consume not a large quantity of tFAs, secrete breast milk not containing much tFA, and the estimated intake of tFAs by infants fed exclusively breast milk is not great.

Keywords

References

  1. Ackmen RG, Hoeper SN (1974): Linolenic acid antifacts from the deodorization of oils. J Am Oil Chem Soc 51(1): 42-49 https://doi.org/10.1007/BF00000011
  2. Anderson GH, Akinson SA, Bryan MH (1981): Energy and macronutrients content of human milk during early lactation from mothers giving birth prematurely and at term. Am J Clin Nutr 34(2): 258-265 https://doi.org/10.1093/ajcn/34.2.258
  3. Ascherio A, Willet WC (1997): Health effects of trans fatty acids. Am J Clin Nutr 66(4s): 1006s-1010s
  4. Bitman J, Wood DL, Hamosh M, Hamosh P, Mehta NR (1983): Composition of the lipid composition of breast milk from mothers of term and preterm infants. Am J Clin Nutr 38(2): 300-312 https://doi.org/10.1093/ajcn/38.2.300
  5. British Nutrition Foundation (1995): Trans fatty acids. BNF, London
  6. Carlson SE, Clandinin MT, Cook HW, Emken EA, Filer LT (1997): Trans fatty acids: infant and fetal development. Am J Clin Nutr 66(3s): 717s-736s https://doi.org/10.1093/ajcn/66.3.717S
  7. Chardigny JM, Wiff RL, Sebedio JL, Martine L, Juaneda P (1985): Trans mono- and polyunsaturated fatty acids in human milk. Eur J Clin Nutr 49(4): 523-531
  8. Chen ZY, Pelletier G, Hollywood R, Ratnayake WM (1995): Trans fatty acid isomers in Canadian human milk. Lipids 30(1): 15-21 https://doi.org/10.1007/BF02537037
  9. Choi MH, Moon SJ, Ahn HS (1991): An ecological study of changes in the components of human milk during the breast feeding and the relationships between the dietary behavior of lactating women and the growth of breast-fed infants. Korean J Nutr 24(2): 77-86
  10. Clark RM, Ferris AM, Fey M, Humdrieser KE, Brown PB, Jensen RG (1982): Changes in the lipids of human milk from 2 to 16 weeks postpartum.J Pediatr Gastroenterol Nutr 1(3): 311-315 https://doi.org/10.1097/00005176-198201030-00006
  11. Ferris AM, Dotts MA, Clark RM, Etrin M (1988): Macronutrients in human milk at 2, 12 and 16 weeks postpartum. JADA 88(6): 694-697
  12. Ferris AM, Jensen RG (1984): Lipid in human milk. A review 1. Sampling, determination, and content. J Pediatr Gastroentrol Nutr 3(1): 108-122 https://doi.org/10.1097/00005176-198401000-00023
  13. Finley DA, Loennerdal B, Dewey KB, Grivetti LE (1985): Breast milk composition: fat content and fatty acid composition in vegetarians and non-vegetarians. Am J Clin Nutr 41(4): 787 -800 https://doi.org/10.1093/ajcn/41.4.787
  14. Folch J, Lees M, Stanley GHS (1957): A simple method for the isolation and purification of total lipids from animal tissues. J BioI Chem 226(3): 497-509
  15. Gibson RA, Kneebone GM (1981): Fatty acid composition of human colostrum and mature breast milk. Am J Clin Nutr 34(2): 252-257 https://doi.org/10.1093/ajcn/34.2.252
  16. Grandgirard A, Bourre JM, Julliard F, Homayound P, Dumont L, Piciotti M, Sebedio JL (1994): Incorporation of trans long-chain n-3 polyunsaturated fatty acids in rat brain structure and retina. Lipids 29(4): 251-258 https://doi.org/10.1007/BF02536329
  17. Hall B (1975): Changing composition of human milk and early development of an appetite control. Lancet 1(7910): 779-781
  18. Hanis T, Zidek V, Sachova J, Klir P, Deyl Z (1989): Effects of dietary trans fatty acids on reproductive performance of Wister rats. Br J Nutr 61(3): 519-529 https://doi.org/10.1079/BJN19890140
  19. Hazer G, Dieterrich I, Dieterrrich I, Haug M (1984): Effects of tthe diet on the composition of human milk. Ann Nutr Metab 28(4): 1861-1885
  20. Houwelingen ACV, Homstra G (1994): Trans fatty acids in early human development, in fatty acids and lipid: Biological aspects. In: Simopoulos C, Karger TE, eds. World Review of Nutrition and Diet. pp. 175-178, Kareer AG, Basel
  21. Innis SM, King DJ (1999): Trans fatty acids in human milk are inversely associated with concentration of essential all-cis n-6 and n-3 fatty acids and determine trans, but not n-6 and n-3, fatty acids in plasma lipids of breast-fed infants. Am J Clin Nutr 70(3): 383-390 https://doi.org/10.1093/ajcn/70.3.383
  22. Jansson L, Akesson B, Holmberg L (1981): Vitamin E and fatty acid composition of human milk. Am J Clin Nutr 34(1): 8-13 https://doi.org/10.1093/ajcn/34.1.8
  23. Jensen RG, Bitrnan J, Carlson SE, Couch SC, Hamosh M, Newburg DS (1995): Human milk lipids. In: Jensen RG, ed. Handbook of Human Milk, pp. 495-576, Academic Press, New York
  24. Jensen RG, Clark RM, Ferris AM (1980): Composition of the lipids in human milk: A review. Lipids 15(5): 345-355 https://doi.org/10.1007/BF02533550
  25. KFDA (2006):http://www.kfda.go.kr/open_contentlkfda/news/press_view. php?seq=1108
  26. Kim SH, Nor KH, Moon JW, Song YS (2001): Trans fatty acids effects in hwnans. Food Industry and Nutr 6(2): 45-52
  27. Koletzko B (1992): Trans fatty acids may impair biosynthesis of long-chain polyunsaturates and growth in man. Acta Paediatr 81(4): 302-306 https://doi.org/10.1111/j.1651-2227.1992.tb12230.x
  28. Korean Nutrition Society (2005): Dietary Reference Intakes for Koreans. Gukjin, Seoul
  29. Korean Nutrition Society (2003): CAN-PRO 2.0, Seoul
  30. Larque E, Zamora S, Gil A (2000): Dietary trans fatty acids affect the essential fatty acid concentration of rat milk. J Nutr 130(4): 847-851 https://doi.org/10.1093/jn/130.4.847
  31. Larque E, Zamora S, Gil A (2001): Dietary trans fatty acids in early life: a review. Early Hum Dev 65(1s): s31-s41 https://doi.org/10.1016/S0378-3782(01)00201-8
  32. Lee GJ, Moon SJ, Lee MJ, Ahn HS (1993): Postpartum changes in maternal diet body fat and antropometric measurements in lactating vs nonlactating women. Korean J Nutr 26(1): 76-88
  33. Lee JA, Huh YR, Lee JI, Kim HA (1996): Lim H-S. Fatty acid intakes and plasma lipid concentration of lactating women and breast fed infants in Kwnagju. Korean J Comm Nutr 1(1): 41-46
  34. Lee SK, Chung TH (1985): Lipid content of breast milk in Korean women. Korean J Pediatr 28(10): 977-987
  35. Lim H-S, Huh YR (1994): Lipid and fatty acid composition of Korean breast milk and infant formula. Korean J Nutr 27(6): 563-573
  36. Lim HS, Lee JA, Huh YR, Lee JI (1993): Intakes of energy, protein, lipid and lactose in Korean breast-fed and formula-fed infants. Korean J Nutr 26(3): 325-337
  37. Lim H-S, Lee JA (1996): Effects of fish oil supplementation to Korean lactating women II. The effects on lipid content and fatty acid composition of breast milk. Korean J Nutr 29(2): 188-191
  38. Loennerdal B (1986): Effects of maternal dietary intake on human milk composition. J Nutr 116(4): 499-513 https://doi.org/10.1093/jn/116.4.499
  39. Mansour MP, Sinclair AJ (1993): The trans fatty acid and positional (sn-2) fatty acid composition of some Australian margarines, dairy blends and animal fats. Asia Pac J Clin Nutr 3(2): 155-163
  40. Moon SJ, Ahn HS, Lee MJ, Kim JH, Kim CJ, Kim SY (1993): A longitudinal study of the total lipid, total cholesterol, and Vitamin E content and fatty acids composition of human milk. Korean J Nutr 26(6): 758-771
  41. Moon SJ, Lee MJ, Kim JH, Kang JS, Ahn HS, Song SW, Choi MH (1992): A longitudinal study of the total nitrogen, total lipid, and lactose contents in human milk and energy intake of breast-fed infants. Korean J Nutr 25(3): 233-247
  42. Moreira NX, Curi R, Padovese R, Mancini-Filho J (2001): Incorporation of dietary trans monounsaturated fatty acids into tissues of Walker 256 tumor-bearing rats. Braz J Med Biol Res 34(4): 501-508 https://doi.org/10.1590/S0100-879X2001000400010
  43. Noh K-H, Won M-S, Song Y-S (2003): Trans fatty acid isomers of processed foods commonly consumed in Korea. J Korean Soc Food Sci Nutr 32(3): 325-337 https://doi.org/10.3746/jkfn.2003.32.3.325
  44. Noh K-H, Song Y-S, Moon J-W (2000): Trans fatty acids intake of a girl's high school students in Pusan by food frequency questionnaire. J Korean Soc Food Sci Nutr 29(5): 957-964
  45. Patton S, Long CA (1978 ): Formation of intracellular fat droplets: Interrelation of newly synthesized phosphatidylcholine and triglyceride in milk. J Dairy Sci 61(10): 13 92-13 99
  46. Precht D, Molkentin J (1999): C18:1, C18:2 and C18:3 trans and cis fatty acid isomers including conjugated cis delta 9, trans delta II linoleic acid (CLA) as well as total fat composition of German human milk lipids. Nahrung 43(4): 233-244 https://doi.org/10.1002/(SICI)1521-3803(19990801)43:4<233::AID-FOOD233>3.0.CO;2-B
  47. Read WWC, Sarrif A (1965): Human milk lipids; I. Changes in fatty acid compo-sition of early colostrum. Am J Clin Nutr 17(3): 177-179 https://doi.org/10.1093/ajcn/17.3.177
  48. Seol MY, Kim ES, Keum HK (1993): A longitudinal study on human milk intake in exclusively breast-fed infants. Korean J Nutr 26(4): 414-422
  49. Slover HR, Carpenter DL (1981): Relative nutritional value of various dietary fats and oils. J Am Oil Chern Soc 58(3): 249-255 https://doi.org/10.1007/BF02582351
  50. Stachowaka E, Chubek D, Ciechanowski K (2001): Trans isomers of unsaturated fatty acids-metabolic action and clinical effects. Pol Merkuriusz Lek 10(57): 173-176
  51. USDA (2004): Trans fatty acids database. http://www. nal. usda. gov
  52. Troisi R, Willett WC, Weiss SC (1992): Trans fatty acid intake in relation to serum lipid concentration in adult men. Am J Clin Nutr 56(5): 1019-1024 https://doi.org/10.1093/ajcn/56.6.1019
  53. Won JS, Ahn MA (1990): A study on contents of trans fatty acids in food served at University dormitory and their composition. Korean J Nutr 23(1): 19-24
  54. Yoon TH (1983): Effects of period of lactation and maternal diet on fatty acid composition of human breast milk. Human Sci 7(1): 53-61
  55. Vijver P, Kardinaal AF, Couet C, Are A, Kafatos A, Seingrimsdottir L, Amorim CJ, Moreiras O, Becker W, Amelsvoort JM, Vidaljessel S, Salminen I, Moschandreas J, Sigfusson N, Martins I, Carbajal A, Ytterfors A, Poppel G (2000): Association between trans fatty acid intake and cardiovascular risk factors in Europe: the TRANIR study. Eur J Clin Nutr 54(2): 126-135 https://doi.org/10.1038/sj.ejcn.1600906