Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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A Study of TNF-${\alpha}$(G308A) Genetic Polymorphism and Risk Factors Associated with Rheumatoid Arthritis by Sasang Constitution

사상체질에 따른 류마티스 관절염의 위해요인 및 TNF-${\alpha}$(G308A) 유전자 다형성간의 연관성 연구

  • Kim, Su-Young (Department of Preventive medicine, College of Medicine, Cheju National University) ;
  • Chun, Hyung-Jon (Department of Occupational and Environmental Medicine, Hangang Sacred Heart Hostpital, Hallym University) ;
  • Lee, Doo-Ik (Department of Anesthesiology & Pain Medicine, College of Medicine, Kyung-Hee University) ;
  • Lee, Yun-Ho (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Kyung-Hee University) ;
  • Choi, Do-Young (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Kyung-Hee University) ;
  • You, Yong-Gu (Director of Backam Orient Medical Clinic) ;
  • Lee, Jae-Dong (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Kyung-Hee University)
  • 김수영 (제주대학교 의과대학 예방의학교실) ;
  • 전형준 (한림대학교 의과대학 산업의학교실) ;
  • 이두익 (경희대학교 의과대학 마취통증의학과) ;
  • 이윤호 (경희대학교 한의과대학 침구과교실) ;
  • 최도영 (경희대학교 한의과대학 침구과교실) ;
  • 유용구 (백암한의원) ;
  • 이재동 (경희대학교 한의과대학 침구과교실)
  • Published : 2007.02.20
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Abstract

Objectives: The purpose of this study is to examine the risk factors and the genetic polymorphism of TNF-alpha associated with rheumatoid arthritis by Sasang constitution Methods : This study was planned to detect the susceptibility of the patients diagnosed by rheumatoid arthritis to Sasang Constitution and to examine the risk factor such as life style and environmental stress (smoking, environmental tobacco smoke, alcohol intake and so on). The genetic polymorphism of TNF-alpha (G308A) were analyzed by PCR-RFLP in rheumatoid arthritis patients and controls. Rheumatoid arthritis patients and matched controls are assessed with QSCCII question for Sasang Typology. Then the genetic polymorphism of patients by Sasang constitution are compared to those of control, which are statistically analyzed and adjusted by age, sex, smoking status, alcohol intake, BMI, and econocmic status. Results: Differential effect of passive smoking on the association between Sasang constitution and rheumatoid arthritis risk was found. This study showed that the genetic polymorphism (TNF-${\alpha}$(G308A)) of rheumatoid arthritis patients and controls associated with the susceptibility to rheumatoid arthritis by sasang constitution was analyzed. Differential effects of TNF-${\alpha}$(G308) genetic polymorphism on the association between rheumatoid arthritis risk and Sasang constitution were found. Conclusion : It is suggested that the genetic polymorphism correlated with susceptibility to rheumatoid arthritis by specific sasang constitution used as its susceptibility marker and further as basic data to prevent the risk factors for rheumatoid arthritis. But larger studies will be needed to confirm these preliminary findings.

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