Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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Effects of Sayeoksanhap-Pyeongweisan-Gamibang(SPG) on Hepatological Changes in Animals Damaged by $CCl_4$

사역산합평위산가미방(四逆散合平胃散加味方)의 경구투여와 약침의 병용이 백서의 간손상에 미치는 영향

  • Kim, Sung-Wook (Department of Acupuncture & Moxibustion, College of Korean medicine, Dongshin University) ;
  • Kim, Hyung-Woo (Department of Herbology, College of Korean medicine, Dongshin University) ;
  • Cho, Su-In (Department of Herbology, College of Korean medicine, Dongshin University) ;
  • Yun, Yeo-Choong (Department of Acupuncture & Moxibustion, College of Korean medicine, Dongshin University)
  • 김성욱 (동신대학교 한의과대학 침구학교실) ;
  • 김형우 (동신대학교 한의과대학 본초학교실) ;
  • 조수인 (동신대학교 한의과대학 본초학교실) ;
  • 윤여충 (동신대학교 한의과대학 침구학교실)
  • Published : 2007.08.20
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Abstract

Objectives: This study was designed to investigate protective effects of Sayeoksanhap-Pyeongweisan-Gamibang(SPG) on hepatological changes in rats damaged by $CCl_4$. Methods : We investigated the effects of SPG on hepatological changes in terms of AST/ALT levels, Total cholesterol, HDL-cholesterol and triglyceride in serum and lipid peroxidation in rat liver. Results : Combination treatment with acupuncture and oral administration of SPG decreased AST and ALT in serum. Combination treatment also decreased lipid peroxidation in liver and triglyceride in serum. In addition, HDL-cholesterol in serum was increased significantly by combination treatment. Contrary, level of total cholesterol was not changed by combination treatment. Conclusion : These results suggest that Combination treatment with acupuncture and oral administration of SPG was useful to protect liver against $CCl_4$ by its antioxidant action in liver tissues.

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