대한의생명과학회지 (Biomedical Science Letters)
- 제13권2호
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- Pages.153-155
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- 2007
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Endoplnsmic Reticulum Stress Up-regulates Ferritin Heavy Chain 1 Expression
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- 권오유 (충남대학교 의과대학 해부학교실)
- Jin, Cho-Yi (Department of Anatomy, College of Medicine, Chungnam National University) ;
- Kwon, Ki-Sang (Department of Anatomy, College of Medicine, Chungnam National University) ;
- Yun, Eun-Young (Department of Sericulture and Entomology, National Institute of Agriculture Science and Technology, R.D.A.) ;
- Goo, Tae-Won (Department of Sericulture and Entomology, National Institute of Agriculture Science and Technology, R.D.A.) ;
- Kwon, O-Yu (Department of Anatomy, College of Medicine, Chungnam National University)
- 발행 : 2007.06.30
초록
Ferritin heavy chain 1 (FTH1) is an ubiquitous and highly conserved protein which plays a major role in iron homeostasis. The expression of FTH1 was specifically enhanced under various condition of endoplasmic reticulum (ER) stresses drugs such as Brefeldin A (BFA), DTT (Dithiothreitol), calcium ionophore A23187 and tunicamycin. We firstly report here that ER-stress induces up-regulated expression of FTH1 in FRTL-5 culture thyrocytes.