Biomedical Science Letters (대한의생명과학회지)
- Volume 13 Issue 2
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- Pages.135-140
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- 2007
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Effects of Intravenous Administration of Taurocholic Acid on Hepatic Catechol-O-Methyltransferase Activity in Rats with Choledocho-Caval Shunt
- Do, Jun-Young (Department of Internal Medicine, Yeungnam University, College of Medicine) ;
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Mun, Kyo-Cheol
(Department of Biochemistry, Keimyung University, School of Medicine) ;
- Kim, You-Hee (Department of Biochemistry, Keimyung University, School of Medicine) ;
- Kwak, Chun-Sik (Department of Biochemistry, Keimyung University, School of Medicine)
- ;
- ;
- ;
- 곽춘식 (계명대학교 의과대학 생화학교실)
- Published : 2007.06.30
Abstract
The possible mechanism of decreased catechol-O-methyltransferase (COMT) activity in cholestatic rat liver was studied. Hepatic and serum COMT activities were determined from the experimental rats with choledocho-caval shunt (CCS). The Michaelis-Menten constants in this hepatic enzyme was also measured. The activities of cytosolic, mitochondrial and mircosomal COMT as well as their