Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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Periodontal Repair on Intrabony Defects treated with Anorganic Bovine-derived Xeonograft

Bovine-derived Xenograft가 치주 골내낭 치유에 미치는 영향

  • Kim, Young-Taek (Department of Periodontology, College of dentistry, Yonsei University, Research Institute for Periodontal Regeneration) ;
  • Chae, Gyung-Joon (Department of Periodontology, College of dentistry, Yonsei University, Research Institute for Periodontal Regeneration) ;
  • Jung, Ui-Won (Department of Periodontology, College of dentistry, Yonsei University, Research Institute for Periodontal Regeneration) ;
  • Lee, Yong-Kun (Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University) ;
  • Cho, Kyoo-Sung (Department of Periodontology, College of dentistry, Yonsei University, Research Institute for Periodontal Regeneration) ;
  • Chai, Jung-Kiu (Department of Periodontology, College of dentistry, Yonsei University, Research Institute for Periodontal Regeneration) ;
  • Kim, Chong-Kwan (Department of Periodontology, College of dentistry, Yonsei University, Research Institute for Periodontal Regeneration) ;
  • Choi, Seong-Ho (Department of Periodontology, College of dentistry, Yonsei University, Research Institute for Periodontal Regeneration)
  • 김영택 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 채경준 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 정의원 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 이용근 (연세대학교 치과대학 생체재료학교실) ;
  • 조규성 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 채중규 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 김종관 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 최성호 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소)
  • Published : 2007.09.30
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Abstract

The ultimate goal of periodontal treatment is to regenerate the lost periodontal apparatus. Many studies were performed in developing an ideal bone substitute. Anorganic bovine-derived xenograft is one of the bone substitute, which were studied and have been shown successful for decades. The aim of this study is to evaluate the effect anorganic bovine-derived xenograft. Total of 20 patients, with 10 patients receiving only modified widman flap, and the other 10 receiving anorganic bovine-derived xenograft and flap surgery, were included in the study. Clinical parameters were recorded before surgery and after 6 months. The results are as follows: 1. The test group treated with anorganic bovine-derived xenograft showed reduction in periodontal pocket depth and clinical attachment level with statistically significance(p<0.001) after 6 months. The control group treated with only modified Widman flap showed reduction only in periodontal pocket depth with statistically significance(p<0.001) after 6 months. 2. Although periodontal probing depth change during 6 months did not show any significant differences between the test group and the control group, clinical attachment level gain and re-cession change showed significant differences between the two groups(p<0.05). On the basis of these results, anorganic bovine-derived xenograft improves probing depth and clinical attachment level in periodontal intrabony defects. Anorganic bovine-derived xenograft could be a predictable bone substitute in clinical use.

Keywords

References

  1. Zander HA, Polson AM, Heijl LC. Goals of periodontal therapy, J Periodontal 1976:47:261-266 https://doi.org/10.1902/jop.1976.47.5.261
  2. Wang HL, Greenwell H, Fiorellini J, et al, Periodontal regeneration. J Periodontol 2005;76:1601-1622 https://doi.org/10.1902/jop.2005.76.9.1601
  3. Hoexter DL, Bone regeneration graft materials, J Oral Implantol 2002:28:290-294 https://doi.org/10.1563/1548-1336(2002)028<0290:BRGM>2.3.CO;2
  4. Rosen PS, Reynolds MA.. Bowers GM, The treatment of intrabony defects with bone grafts, Periodontal 2000;22:88-103 https://doi.org/10.1034/j.1600-0757.2000.2220107.x
  5. Zohar R, Tenenbaum HC. How predictable are periodontal regenerative procedures? J Can Dent Assoc 2005;71:675-680
  6. Kim CS, Choi SH. Cho KS. et al Periodontal healing in one-wall intra-bony defects in dogs following implantation of autogenous bone or a coral -derived biomaterial, J Gin Periodontal 2005:32:583-589 https://doi.org/10.1111/j.1600-051X.2005.00729.x
  7. 김현수, 최병갑, 최성호, 조규성, 서종진. BBP가 치주 골내낭 치유에 미치는 영향. 대한치주과학회지 2002;32:213-224
  8. Kim CK, Cho KS, Choi SH, Prewett A, Wikesjo UM. Periodontal repair in dogs: effect of allogenic freeze-dried demineralized bone matrix implants on alveolar bone and cementum regeneration, J Periodontol 1998:69:26-33 https://doi.org/10.1902/jop.1998.69.1.26
  9. 김성희, 김종관, 채중규, 조규성, 골내 치주낭에서 탈회냉동건조골 동종이식시 이식효과에 대한 임상적 연구. 대한치주과학회지 1994:24:618-633
  10. Buck BE, Malinin TI, Brown MD, Bone transplantation and human immunodeficiency virus. An estimate of risk of acquired immunodeficiency syndrome (AIDS). Gin Orthop Relat Res 1989:29-136
  11. Mellonig JT. Donor selection, testing. and inactivation of the HIV virus in freezedried bone allografts. Pract Periodontics Aesthet Dent 1995:7:13-22; quiz 23
  12. Kim CK, Choi EJ, Cho KS, Chai JK, Wikesjo UM. Periodontal repair in intrabony defects treated with a calcium carbonate implant and guided tissue regeneration. J Periodontol 1996:67:1301-1306 https://doi.org/10.1902/jop.1996.67.12.1301
  13. Moon IS, Chai JK, Cho KS, Wikesjo UM, Kim CK, Effects of polyglactin mesh combined with resorbable calcium carbonate or replamineform hydroxyapatite on periodontal repair in dogs. J Clin Periodontal 1996:23:945-951 https://doi.org/10.1111/j.1600-051X.1996.tb00516.x
  14. Han DK, Kim CS, Jung UW, et al. Effect of a fibrin-fibronectin sealing system as a carrier for recombinant human bone morphogenetic protein-4 on bone formation in rat calvarial defects. J Periodontal 2005: 76:2216-2222 https://doi.org/10.1902/jop.2005.76.12.2216
  15. Hyun SJ, Han DK, Choi SH, et al, Effect of recombinant human bone morphogenetic protcin-2, -4, and -7 on bone formation in rat calvarial defects J Periodontol 2005: 76:1667-1674 https://doi.org/10.1902/jop.2005.76.10.1667
  16. Pang EK, Im SU, Kim CS, et al Effect of recombinant human bone morphogenetic protein-4 dose on bone formation in a rat calvarial defect model J Periodontol 2004; 75:1364-1370 https://doi.org/10.1902/jop.2004.75.10.1364
  17. Asher DM. Padilla AM, Pocchiari M. WHO Consultation on Diagnostic Procedures for Transmissible Spongiform Encephalopathies: Need for Reference Reagents and Reference Panels. Geneva, Switzerland, 22-23 March 1999. Biologicals 1999:27:265-272
  18. Sogal A, Tofe AJ. Risk assessment of bovine spongiforrn encephalopathy transmission through bone graft material derived from bovine bone used for dental applications, J Periadontol 1999;70:1053-1063 https://doi.org/10.1902/jop.1999.70.9.1053
  19. Pinholt EM, Bang G, Haanaes HR. Alveolar ridge augmentation in rats by Bio-Oss, Scand J Dent Res 1991;99:154-161
  20. Sculcan A, Berakdar M, Chiantella GC, et al Healing of intrabony defects following treatment with a bovine-derived xenograft and collagen membrane. A controlled dinical study. J Clin Periodontal 2003:30:73-80 https://doi.org/10.1034/j.1600-051X.2003.10192.x
  21. Sculean A, Chiantella GC, Windisch P, et al, Healing of intra-bony defects following treatment with a composite bovine-derived xenograft (Bio-Oss Collagen) in combination with a collagen membrane (Bio-Gide PERIO) , J Clin Periodontal 2005:32:720-724 https://doi.org/10.1111/j.1600-051X.2005.00758.x
  22. Sculean A, Stavropoulos A, Windisch P, et al, Healing of human intrabony defects following regenerative periodontal therapy with a bovine-derived xenograft and guided tissue regeneration. Clin Oral Investig 2004;8:70-74
  23. Richardson CR. Mellonig JT, Brunsvold MA, McDonnell HT, Cochran DL, Clinical evaluation of Bio-Oss: a bovine-derived xenograft for the treatment of periodontal osseous defects in humans, J Clin Periodontol 1999:26:421-428 https://doi.org/10.1034/j.1600-051X.1999.260702.x
  24. Young C, Sandstedt P, Skoglund A, A comparative study of anorganic xenogenic bone and autogenous bone implants for bone regeneration in rabbits. Int J Oral Maxillofac Implants 1999:14:72-76
  25. Jensen SS. Broggini N, Hjorting- Hansen E, Schenk R, Buser D. Bone healing and graft resorption of autograft, anorganic bovine bone and beta-tricalcium phosphate, A histologic and histomorphometric study in the mandibles of minipigs. Clin Oral Implants Res 2006:17:237-243 https://doi.org/10.1111/j.1600-0501.2005.01257.x
  26. Mellonig JT, Human histologic evaluation of a bovine-derived bone xenograft in the treatment of periodontal osseous defects, Int J Periodontics Restorative Dent 2000: 20:19-29
  27. Hartman GA, Arnold RM, Mills MP, Cochran DL, Mellonig JT, Clinical and histologic evaluation of anorganic bovine bone collagen with or without a collagen barrier, lnt J Periodontics Restorative Dent 2004; 24:127-135
  28. 박호남, 안상혁, 김경화. et al. 생체 유래 골이식재(OCS-B)의 안정성및 유효성에 관한 연구. 대한치주과학회지 2005;35:335-343
  29. Shapoff CA, Bowers GM, Levy B, Mellonig JT, Yukna RA, The effect of particle size on the osteogenic activity of composite grafts of allogeneic freeze-dried bone and autogenous marrow, J Periodontal 1980;51: 625-630 https://doi.org/10.1902/jop.1980.51.11.625
  30. Mellonig JT. Decalcified freeze-dried bone allograft as an implant material in human periodontal defects Int J Periodontics Restorative Dent 1984:4:40-55
  31. Fucini SE, Quintero G, Gher ME, Black BS, Richardson AC, Small versus large particles of demineralized freeze-dried bone allografts in human intrabony periodontal defects. J Periodontol 1993;64:844-847 https://doi.org/10.1902/jop.1993.64.9.844
  32. Westfelt E. Bragd L, Socransky SS, et al, Improved periodontal conditions following therapy. J Clin Periodontol 1985;12:283-293 https://doi.org/10.1111/j.1600-051X.1985.tb02294.x
  33. Froum SJ, Coran M, Thaller B, et al, Periodontal healing following open debridement flap procedures, I. Clinical assessment of soft tissue and osseous repair. J Periodontol 1982;53:8-14 https://doi.org/10.1902/jop.1982.53.1.8
  34. Rosling B, Nyman S, Lindhe J, Jern B. The healing potential of the periodontal tissues following different techniques of periodontal surgery in plaque-free dentitions, A 2-year clinical study, J Clin Periodontol 1976;3:233-250 https://doi.org/10.1111/j.1600-051X.1976.tb00042.x
  35. Carranza FA, Newman MG, Takei HH, Klokkevold PR, Carranza's Clinical Periodontology: Sanders; 2006: 579-608