염산 테트라싸이클린이 SLA 임플란트의 표면 구조에 미치는 영향

The effects of tetracycline-HCI on SLA implant surface structure

  • 서미란 (경희대학교 치의학전문대학원 치주과학교실, 구강생물학연구소) ;
  • 권영혁 (경희대학교 치의학전문대학원 치주과학교실, 구강생물학연구소) ;
  • 박준봉 (경희대학교 치의학전문대학원 치주과학교실, 구강생물학연구소) ;
  • 허익 (경희대학교 치의학전문대학원 치주과학교실, 구강생물학연구소) ;
  • 정종혁 (경희대학교 치의학전문대학원 치주과학교실, 구강생물학연구소)
  • Sea, Mi-Ran (Department of Periodontology and Institute of Oral Biology, School of Dentistry, Kyung Hee University) ;
  • Kwon, Young-Hyuk (Department of Periodontology and Institute of Oral Biology, School of Dentistry, Kyung Hee University) ;
  • Park, Joon-Bong (Department of Periodontology and Institute of Oral Biology, School of Dentistry, Kyung Hee University) ;
  • Herr, Yeek (Department of Periodontology and Institute of Oral Biology, School of Dentistry, Kyung Hee University) ;
  • Chung, Jong-Hyuk (Department of Periodontology and Institute of Oral Biology, School of Dentistry, Kyung Hee University)
  • 발행 : 2007.06.30

초록

The present study was performed to evaluate the effects of Tetracycline-HCI on the microstructure change of SLA implant surface according to application time. In the Tetracycline-HCI group, 6 implants were rubbed with sponges soaked $50mg/m{\ell}$ Tetracycline-HCI solution for O.5min., lmin., 1. 5min., 2min., 2.5min. and 3min. In the saline group. another 6 implants conditioned with sponges soaked saline using same methods. One implant wasn't conditioned anything. Then, the changes of surface roughness values were evaluated by optical interferometer & specimens were processed for scanning electron microscopic observation. The results of this study were as follows: 1. In both Tetracycline-HCI group & saline group, there are no significant differences between surface roughness values before & after surface detoxification. And in scanning electron microscopic observation. there are slightly changes of implant surface structures but this changes were not significant by comparison with no treatment implant surface. 2. In the changes of surface roughness values & the scanning electron microscopic observation, there were no significant differences between saline & Tetracycline-HCI groups. In conclusion, the detoxification with $50mg/m{\ell}$ Tetracycline-HCI within 3 minutes can be applied for treatment of peri-implantitis in SLA surface implants. without surface microstructure changes.

키워드

참고문헌

  1. Branemark PI, Hansson BO, Adell R, et al, Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Scand J Plast Reconstr Surg 1977;16:1-132
  2. Albrektsson T, Zarb G, Worthington P, Eriksson AR. The long-term efficacy of currently used dental implants: A review and proposed criteria of success. Int J Oral Maxillofac Implants 1986;1:11-25
  3. Meffert RM, Langer B, Fritz ME. Dental implants: A review. J Periodontol 1992;63: 859-870 https://doi.org/10.1902/jop.1992.63.11.859
  4. Brånemark PI. Osseointegration & its experimental background. J Prosthet Dent 1983; 50:399-410 https://doi.org/10.1016/S0022-3913(83)80101-2
  5. Steflik DE, Sisk AL, Parr GR, et al, High-voltage electron microscopy & conventional transmission electron microscopy of the interface zone between bone & endosteal dental implants. J Biomed Mater Res 1992;26:529-545 https://doi.org/10.1002/jbm.820260409
  6. Raghavendra S, Wood MC, Taylor TD. Early wound healing around endosseous implants: A review of the literature. Int J Oral Maxillofac Implants 2005;20:425-431
  7. Nancy E. McDermott, Sung-Kiang Chuang, Valerie V. Woo, Thomas B. Dodson. Complications of dental implants: Identification, frequency, & associated risk factors. Int J Oral Maxillofac Implants 2003;18:848-855
  8. Albrektsson T, Isidor F, Consensus report of session IV. In: Lang NP & Karring T. eds, Proceeding of the 1st European Workshop on Periodontology, London: Quintessence Books. 1994;365-369
  9. Sánchez-Garcés MaÁ & Gay-Escoda C, Peri-implantitis. Med Oral Patol Oral Bucal 2004;9:63-74
  10. Quirynen M, Naert I, Van Steenberghe D. Fixture design and overload influence marginal bone loss and fixture success in the Brånemark system. Clin Oral Implants Res 1992;3:104-111 https://doi.org/10.1034/j.1600-0501.1992.030302.x
  11. Isidor F. Loss of osseointegration caused by occlusal load of oral implants. Clin Oral Implants Res 1996;7:143-152 https://doi.org/10.1034/j.1600-0501.1996.070208.x
  12. Mombelli A, Van Oosten MAC, Sch rch EJ, Lang NP. The microbiota associated with successful or failing osseointegrated titanium implants. Oral Microbiol Immunol 1987;2:145-151 https://doi.org/10.1111/j.1399-302X.1987.tb00298.x
  13. Hickey JS, O'Neal RE, Scheidt MJ, et al, Microbiologic characterization of ligature induced peri-implantitis in the microswine model. J Periodontol 1991;62:548-553 https://doi.org/10.1902/jop.1991.62.9.548
  14. Andrea Mombelli, Microbiology & antimicrobial therapy of peri-implantitis. Periodontology 2000 2002;28:177-189 https://doi.org/10.1034/j.1600-0757.2002.280107.x
  15. Roos-Jansaker AM, Renvert S, Egelberg J. Treatment of peri-implant infections: A literature review. J Clin Periodontol 2003; 6:467-485
  16. Zablotsky MH, Diedrich DL, Meffert RM. Detoxification of endotoxin-contaminated titanium & hydroxyapatite-coated surfaces utilizing various chemotherapeutic & mechanical modalities. Implant Dent 1992;1: 154-158 https://doi.org/10.1097/00008505-199205000-00009
  17. Krozer A, Hall J, Ericsson I. Chemical treatment of machined titanium surfaces. An in vitro study. Clin Oral Implants Res 1999;3:204-211
  18. Thomson-Neal D, Evans GH, Meffert RM. Effects of various prophylactic treatments on titanium, sapphire, and hydroxyapatite-coated implants: An SEM study. Int J Periodontics Restorative Dent 1989;4:300-311
  19. Dennison DK, Huerzeler MB, Quinones C, Caffesse RG. Contaminated implant surfaces: An in vitro comparison of implant surface coating and treatment modalities for decontamination. J Periodontol 1994;10: 942-948
  20. D rtbudak O, Haas R, Bernhart T, Mailath-Pokorny G. Lethal photo-sensitization for decontamination of implant surfaces in the treatment of peri-implantitis. Clin Oral Implants Res 2001;2:104-108
  21. Buser D, Schenk RK, Steinemann S, et al, Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs. J Biomed Mater Res 1991;7:889-902
  22. Cochran DL, Schenk RK, Lussi A, Higginbottom FL, Buser D. Bone response to unloaded and loaded titanium implants with a sandblasted and acid-etched surface: A histometric study in the canine mandible. J Biomed Mater Res 1998; 1:1-11 https://doi.org/10.1002/jbm.820010102
  23. Rimondini L, Fare S, Brambilla E, et al, The effect of surface roughness on early in vivo plaque colonization on titanium. J Periodontol 1997;6:556-562
  24. Baker P, Evans R, Coburn R, Genco R. Tetracycline & its derivatives strongly bind to & are released from tooth surface in active form. J Periodontol 1983;54:580-585 https://doi.org/10.1902/jop.1983.54.10.580
  25. Glaub LM, Lee HM, Lehrer G, et al, Minocycline reduces gingival collagenolytic activity during diabetes. J Periodontal Res 1983;18:516-526 https://doi.org/10.1111/j.1600-0765.1983.tb00388.x
  26. Al-Ali W, Bissada NF, Greenwell H. The effect of local doxycycline with & without tricalcium phosphate on the regenerative healing potential of periodontal osseous defects in dogs. J Periodontol 1989;60: 582-590 https://doi.org/10.1902/jop.1989.60.10.582
  27. Pepelassi EM, Bissada NF, Greenwell H, Farah CF. Doxycycline-tricalcium phosphate composite graft facilitates osseous healing in advanced periodontal furcation defects. J Periodontol 1991;62:106-115 https://doi.org/10.1902/jop.1991.62.2.106
  28. Teughels W, Assche NV, Sliepen I, Quirynen M. Effect of material characteristics and/or surface topography on biofilm development, Clin Oral Implants Res 2006;17:68-81 https://doi.org/10.1111/j.1600-0501.2006.01353.x
  29. Shibli JA, Marcantonio E, d'Avila S, Guastaldi AC, Marcantonio E Jr. Analysis of failed commercially pure titanium dental implant: A scanning electron microscopy & energy-dispersive spectrometer x-ray study. J Periodontol 2005;76:1092-1099 https://doi.org/10.1902/jop.2005.76.7.1092
  30. Arvs A, Philippart C, Dourov N, et al, Analysis of titanium dental implants after failure of osseointegration: Combined histological, electron microscopy, & x-ray photoelectron spectroscopy approach. J Biomed Master Res 1998;43:300-312 https://doi.org/10.1002/(SICI)1097-4636(199823)43:3<300::AID-JBM11>3.0.CO;2-J
  31. Esposito M, Lausmaa J, Hirsch JM, Thomsen P, Surface analysis of failed oral titanium implants. J Biomed Mater Res 1999;48:559-568 https://doi.org/10.1002/(SICI)1097-4636(1999)48:4<559::AID-JBM23>3.0.CO;2-M
  32. MacDonald DE, Betts F, Doty SB, Boskey AL. A methodological study for the analysis of apatite-coated dental implants retrieved from human. Ann Periodontol 2000;5:175-184 https://doi.org/10.1902/annals.2000.5.1.175
  33. Proussaefs PT, Tatakis DN, Lozada J, Caplanis N, Rohrer MD. Histologic evaluation of hydroxyapatite-coated root-form implants retrieved after 7 years in function: A case report, Int J Oral Maxillofac Implants 2000; 15: 438-443
  34. Bair RE & Meyer AE, Implant surface preparation. Int J Oral Maxillofac Implants 1988;3:9-20
  35. Sennerby L & Lekholm U. The soft tissue response to titanium abutments retrieved from humans & reimplanted in rats. A light microscopic pilot study, Clin Implants Res 1993;4:23-27 https://doi.org/10.1034/j.1600-0501.1993.040103.x
  36. Persson LG, Berglundh T, Lindhe J, Sennerby L. Re-osseointegration after treatment of peri-implantitis at different implant surfaces. An experimental study in the dog. Clin Oral Implants Res 2001;6: 595-603
  37. Krozer A, Hall J, Ericsson I. Chemical treatment of machined titanium surfaces. An in vitro study. Clin Oral Implants Res 1999;3:204-211
  38. Mellonig JT, Griffiths G, Mathys E, Spitznagel J Jr. Treatment of the failing implant: Case reports. Int J Periodontics Restorative Dent 1995;4:384-395
  39. Muller E, Gonz lez YM, Andreana S. Treatment of peri-implantitis: Longitudinal clinical and microbiological findings. A case report. Implant Dentistry 1999;3: 247-254
  40. Somerman MJ, Foster RA, Vorsteg GM, Progebin K, Wynn RL. Effects of minocycline on fibroblast attachment and spreading. J Periodontal Res 1988;2:154-159