Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지

The effect of nutraceutical containing PRF-K2 on periodontal condition during maintenance phase

치주 유지관리기 환자에게 PRF-K2를 함유한 nutraceutical의 효과

  • Kim, Yu-Kang (Department of Periodontology, School of Dentistry, Chonnam National University) ;
  • Chung, Hyun-Ju (Department of Periodontology, School of Dentistry, Chonnam National University, Dental Research Institute, Chonnam National University and 2nd stage of Brain Korea 21 for School of Dentistry) ;
  • Kim, Se-Won (Oscotec Inc. and Department of Dental Pharmacology, Dankook University School of Dentistry) ;
  • Baek, Dong-Heon (Department of Oral Microbiology and Immunology, Dankook University School of Dentistry)
  • 김유강 (전남대학교 치의학전문대학원 치주과학교실) ;
  • 정현주 (전남대학교 치의학전문대학원 치주과학교실, 전남대학교 치의학연구소 및 치의학전문대학교 2단계 BK 21) ;
  • 김세원 ((주)오스코텍, 단국대학교 치과대학 치과약리학교실) ;
  • 백동현 (단국대학교 치과대학 구강미생물학교실)
  • Published : 2007.03.30
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Abstract

The long term success of periodontal treatment is dependent upon the effectiveness of the main-tenance care program after active treatment. The purpose of this study was to evaluate whether nutraceutical containing PRF-K2 as natural product from plant and seaweed has beneficial effects on clinical parameters, gingival crevicular fluid (GCF) volume and GCF cytokine levels during main- tenance phase after periodontal treatment. Among the generally healthy and non-smoking. moderate to severe chronic periodontitis patients during maintenance phase in Department of Periodontics, Chonnam National University Hospital, twenty eight patients took nutraceutical containing PRF-K2 (Oscotec Inc. Cheonan, Korea) for 3 months as experimental group and sixteen patients received only maintenance care as control group. Clinical examination and GCF collection were performed at baseline, 1, 2 and 3 months of experiment. Total amounts and concentrations of GCF IL-1{\beta}, IL-1ra and $PGE_2$ were evaluated using ELISA kit. In probing pocket depth, experimental group showed the tendency of more reduction than control group after 3 months of experiment. Sulcus bleeding index (SBI) and GCF volume were significantly decreased in experimental group(p<0.05), whereas they were increased in control group. GCF IL-1{\beta} level tended to decrease in both experimental and control group and IL-1ra concentration tended to increase in experimental group and to decrease in control group. IL-1ra/IL-1{\beta} ratio tended to increase in experimental group and to decrease in control group during experimental period. GCF $PGE_2$ amount did not show any change in experimental group and tended to increase in control group. These results suggest that nutraceutical supplement which contain PRF-K2 could improve perio-dontal condition during maintenance phase after periodontal therapy.

Keywords

References

  1. Newman MG, Takei HH, Klokkevold PR, Carranza FA. Carranza's clinical periodontology 10th ed, Saunders 2006:275-282
  2. Listgarten MA. Nature of periodontal diseases: pathogenic mechanisms. J Periodontal Res 1987;22:172-178 https://doi.org/10.1111/j.1600-0765.1987.tb01560.x
  3. Honig J, Rordorf-Adam C, Siegmund C, Wiedemann W, Erard F. Increased interleukin-1 beta concentration in gingival tissue from periodontitis patients. J Periodontal Res 1989;62:362-367
  4. Masada MP, Persson R, Kenney JS et al, Measurement of interleukin-l$\alpha$ and 1$\beta$ in gingival crevicular fluid: Implication for the pathogenesis of periodontal disease. J Periodontal Res 1990;25:156-163 https://doi.org/10.1111/j.1600-0765.1990.tb01038.x
  5. Engebretson SP, Grbic JT, Singer R, Lamster IB. GCF IL-1$\beta$ profiles in periodontal disease. J Clin Periodontol 2002;29: 48-53 https://doi.org/10.1034/j.1600-051x.2002.290108.x
  6. Hou L-T, Liu C-M, Rossomando EF. Crevicular interleukin-1$\beta$ in moderate and severe periodontitis patients and the effect of phase I periodontal treatment. J Clin Periodontol 1995;22:162-167 https://doi.org/10.1111/j.1600-051X.1995.tb00128.x
  7. Alexander DCC, Martin JC, King PJ et al, Interleukin-1 beta, prostaglandin E2, and immunoglobulin G subclasses in gingival crevicular fluid in patients undergoing periodontal therapy. J Periodontol 1996;67: 755-762 https://doi.org/10.1902/jop.1996.67.8.755
  8. Ishihara Y, Nishihara T, Kuroyanagi T et al, Gingival crevicular interleukin-1 and interleukin-1 receptor antagonist levels in periodontally healthy and diseased sites. J Periodontal Res 1997;32:524-529 https://doi.org/10.1111/j.1600-0765.1997.tb00568.x
  9. Rawlinson A, Dalati MEN, Rahman S et al, Interleukin-1 and IL-1 receptor antagonist in gingival crevicular fluid. J Clin Periodontol 2000;27:738-743 https://doi.org/10.1034/j.1600-051x.2000.027010738.x
  10. Goodson JM, Dewhirst FE, Brunetti A Prostaglandin E2 levels and human periodontal disease. Prostaglandins 1974; 6: 81-85 https://doi.org/10.1016/S0090-6980(74)80043-2
  11. Offenbacher S, Odle BM, van Dyke TE. The use of crevicular fluid prostaglandin E2 levels as a predictor of periodontal attachment loss. J Periodontal Res 1986;21:101-112 https://doi.org/10.1111/j.1600-0765.1986.tb01443.x
  12. Pedrazzoli V, Kilian M, Karring T, Kirkegaard E. Effect of surgical and non-surgical periodontal treatment on periodontal status and subgingival microbiota. J Clin Periodontol 1991;18:598-604 https://doi.org/10.1111/j.1600-051X.1991.tb00096.x
  13. Badersten A, Nilv us R, Egelberg J. Effect of nonsurgical periodontal therapy I . Moderately advanced periodontitis. J Clin Periodontol 1981;8:57-72 https://doi.org/10.1111/j.1600-051X.1981.tb02024.x
  14. Becker W, Becker BE, Ochsenbein C et al A longitudinal study comparing scaling, osseous surgery and modified Widman procedures: Results after one year. J Periodontol 1988;59:351-365 https://doi.org/10.1902/jop.1988.59.6.351
  15. Axelsson P, Lindhe J. The significance of maintenance care in treatment of periodontal disease. J Clin Periodontol 1981;8: 281-294 https://doi.org/10.1111/j.1600-051X.1981.tb02039.x
  16. Ramfjord SP. Maintenance care for treated periodontitis patients. J Clin Periodontol 1987;14:433-437 https://doi.org/10.1111/j.1600-051X.1987.tb02247.x
  17. Wilson TG Jr. Maintaining periodontal treatment. J Am Dent Assoc 1990;121:491-494 https://doi.org/10.14219/jada.archive.1990.0182
  18. Neiva RF, Al-Shammari K, Nociti FH Jr, Soehren S, Wang HL. Effects of vitamin-B complex supplementation on periodontal wound healing. J Periodontal 2005;76:1084-1091 https://doi.org/10.1902/jop.2005.76.7.1084
  19. Nishida M, Grossi SG, Dunford RG et al, Dietary vitamin C and the risk for periodontal disease. J Periodontal 2000;71:1215-1223 https://doi.org/10.1902/jop.2000.71.8.1215
  20. Krall EA, Wehler C, Garcia RI, Harris SS, Dawson-Hughes B. Calcium and vitamin D supplements reduce tooth loss in the elderly. Am J Med 2001;111:452-456 https://doi.org/10.1016/S0002-9343(01)00899-3
  21. Munoz CA, Kiger RD, Stephens JA, Kim J, Wilson AC. Effects of nutritional supplement on periodontal status. Compend Contin Educ Dent. 2001;22:425-438
  22. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6 https://doi.org/10.1902/annals.1999.4.1.1
  23. Muhlemann HR, Son S. Gingival sulcus bleeding- a leading symptom in initial gingivitis, Helv Odontol Acta 1971;15:107-113
  24. Miller WD. Experimental and observations on the wasting of tooth tissue variously designated as erosion, abrasion, chemical abrasion, denudation, etc. D Comos 1907; 49:1-23
  25. Caton JG, Ciancio SG, Blieden TM et al, Treatment with subantimicrobial dose doxycycline improves the efficacy of scaling and root planing in patients with adult periodontitis. J Periodontol 2000;71:521-532 https://doi.org/10.1902/jop.2000.71.4.521
  26. Soder PO, Frithiof L, Wikner S et al, The effects of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis in young adults. J Periodontol 1990;61:281-288 https://doi.org/10.1902/jop.1990.61.5.281
  27. 김지현, 정현주. 만성 치주염에서 비외과적 또는 외과적 치주치료 후 유지관리기 동안 임상적 변화의 비교. 대한치주과학회지 2006; 36(1): 69-84
  28. Lamster IB. Evaluation of components of gingival crevicular fluid as diagnostic tests Ann Periodontol 1997;2:123-137 https://doi.org/10.1902/annals.1997.2.1.123
  29. Brill N. Gingival conditions related to flow of tissue fluid into gingival pockets. Acta Odontol Scand 1960;18:421-446 https://doi.org/10.3109/00016356009043875
  30. Loe H, Holm-Pedersen P, Absence and presence of fluid from normal and inflamed gingivae. Periodontics 1965;3:171-177
  31. Mann WV. The correlation of gingivitis pocket depth and exudate from the gingival crevice. J Periodontol 1963;34:379-387 https://doi.org/10.1902/jop.1963.34.4.379
  32. Griffiths GS, Formation, collection and significance of gingival crevice fluid. Periodontol 2000 2003;31:32-42
  33. Stashenko P, Jandinski JJ, Fujiyoshi P, Rynar J, Socransky SS. Tissue levels of one resorptive cytokines in periodontal disease. J Periodontol 1991;62:504-509 https://doi.org/10.1902/jop.1991.62.8.504