Polymer(Korea) (폴리머)

The Polymer Society of Korea (한국고분자학회)
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BCNU Release Behaviour from BCNU/PLGA Wafer Prepared by Vacuum Drying Method

진공 건조법에 의해 제조된 BCNU/PLGA웨이퍼의 BCNU 방출거동

  • Park, Jung-Soo (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Shin, Joon-Hyun (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Lee, Doo-Hee (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Rhee, John-M. (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Kim, Moon-Suk (Nanobiomaterials Lab, Korea Research institute of Chemical Technology) ;
  • Lee, Hai-Bang (Nanobiomaterials Lab, Korea Research institute of Chemical Technology) ;
  • Khang, Gil-Son (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
  • 박정수 (BK-21 고분자 BIN 융합연구팀) ;
  • 신준현 (BK-21 고분자 BIN 융합연구팀) ;
  • 이두희 (BK-21 고분자 BIN 융합연구팀) ;
  • 이종문 (BK-21 고분자 BIN 융합연구팀) ;
  • 김문석 (한국화학연구원 생체분자전달제어팀) ;
  • 이해방 (한국화학연구원 생체분자전달제어팀) ;
  • 강길선 (BK-21 고분자 BIN 융합연구팀)
  • Published : 2007.05.31
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Abstract

Biodegradable polymers such as polylactide, polyglycolide and poly (lactide- co-glycolide) (PLGA) have been extensively investigated because of easily controlled drug release rate, completely degradable materials without the toxic by-product, and good biocompatibility. But, according to the bulk erosion property of PLGA in vitro test, it had the disadvantage that first-order release reduced releasing amount slowly after excessive initial burst. In this study we used PLGA powder obtained through recrystallization to revise bulk erosion property of PLGA. The PLGA used in this study was prepared by vacuum drying method and to estimate release profiles of BCNU loaded PLGA wafer. We also evaluated the release profile of drug with the water soluble additive. It was found that the drug loaded PLGA recrystallized by vacuum drying method exhibited the initial burst and the constant rate of drug release compared to that prepared by a conventional method.

폴리락타이드, 폴리글리콜라이드, 및 글리콜라이드-락타이드 공중합체(PLGA)와 같은 생분해성 고분자들은 쉬운 약물방출량 조절과 부산물독성이 없이 지지체의 완벽한 분해과 좋은 생체적합성을 갖고 있다. 그러나 PLGA는 in vitro 실험에서의 괴상침식, 과도한 초기방출 후의 방출량이 감소하는 단점을 갖고 있다. 본 연구에서 PLGA 재결정 분말은 진공건조법을 이용하여 제조하였으며 1,3-bis(2-chloroethyl)-1-nitro-sourea(BCNU, carmustine)가 함유된 PLGA 웨이퍼의 방출거동을 알아보았으며 동시에 수용성 첨가제를 넣어 약물의 방출거동을 알아보고자 하였다. 진공건조법으로 재결정한 PLGA 웨이퍼가 일반방법으로 제조한 PLGA 웨이퍼보다 수분흡수율 감소와 웨이퍼 자체 초기의 분해 속도 감소로 인하여 초기 방출량이 감소하고 지속적 방출거동을 가지는 것을 확인하였다.

Keywords

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