대한한의학회지 (The Journal of Korean Medicine)
- 제28권1호통권69호
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- Pages.237-248
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- 2007
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- 1010-0695(pISSN)
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- 2288-3339(eISSN)
익수지선단(益壽地仙丹)이 Streptozotocin으로 유발된 당뇨병 흰쥐의 신기능, 활성산소, 활성질소 및 Polyol Pathway에 미치는 영향
Effects of Iksujisundan on Renal Function, Peroxynitrite Scavenging Activity and Polyol Pathway in Streptozotocin-induced Diabetic Rats
- Jeon, Chang-Min (Dept. of Internal Medicine, College of Korean Medicine, Dongguk University) ;
- Jeong, Ji-Cheon (Dept. of Internal Medicine, College of Korean Medicine, Dongguk University)
- 발행 : 2007.03.30
초록
Objectives : Diabetes is a disease in which the body does not produce or properly use insulin. Etiological studies of diabetes and its complications showed that oxidative stress might play a major role. Therefore, many efforts have been tried to regulate free oxygen radicals for treating diabetes and its complications. Iksujisundan has been known to be effective for the treatment of diabetes. The present study was carried out to investigate the effect of Iksujisundan on renal function, peroxynitrite(ONOO-) scavenging activity and polyol pathway in streptozotocin-induced diabetic rats. Methods : The crushed Iksujisundan was extracted 3 times, each time with 3 volumes of methyl alcohol at 60