The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Effects of Rhizoma Arisaematis on Lipid and Glucose Metabolism and Histochemical Changes of Rats Fed High Fat Diet

천남성이 고지방식이로 유발된 비만 흰쥐의 당지질대사 및 조직화학적 변화에 미치는 효과

  • Lee, Jeong-Ho (Dept. of Oriental Rehabilitaion Medicine, College of Oriental Medicine, Dongguk University) ;
  • Kim, Ho-Jun (Dept. of Oriental Rehabilitaion Medicine, College of Oriental Medicine, Dongguk University) ;
  • Lee, Myeong-Jong (Dept. of Oriental Rehabilitaion Medicine, College of Oriental Medicine, Dongguk University)
  • 이정호 (동국대학교 한의과대학 한방재활의학교실) ;
  • 김호준 (동국대학교 한의과대학 한방재활의학교실) ;
  • 이명종 (동국대학교 한의과대학 한방재활의학교실)
  • Published : 2007.03.30
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Abstract

Objectives : This study was performed to investigate the effects of Rhizoma Arisaematis water extract on lipid and glucose metabolism and histochemical change of obese rats. Methods and materials : 10 rats were divided into normal, control and RA (Rhizoma Arisaematis) groups. We fed the control group a high-fat diet and administered normal saline for 8 weeks. We fed the experimental group of rats a high-fat diet and administered an extract of Rhizoma Arisaematis for 8 weeks. At the end of the experiment, the rats were sacrificed to determine their chemical composition. The groups were examined for effects on blood serum lipids, blood sugar, blood insulin concentration and epididymal fat cells. Results : 1. Serum total cholesterol, triglyceride, HDL-cholesterol and glucose of the RA group decreased compared with those of the control group. These decreased rates were significant(P<0.05). 2. Serum LDL-cholesterol, total lipid, free fatty acid and the average size of epididymal fat cells of the RA group decreased compared with those of the control group. These decreased rates were significant(p<0.01). Conclusions : These results suggest that RA may be used to prevent or cure the obesity iniduced by a high-fat diet.

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