대한한의학회지 (The Journal of Korean Medicine)
- 제28권1호통권69호
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- Pages.148-158
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- 2007
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- 1010-0695(pISSN)
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- 2288-3339(eISSN)
상엽(桑葉)추출물의 항산화효과에 대한 연구
Studies on the Antioxidant Effects of Mori Folium Extract
- Lee, Ji-Eun (Dept. of Rehabilitation Medicine, College of Oriental Medicine, Kyung-Won University) ;
- Lim, Hyung-Ho (Dept. of Rehabilitation Medicine, College of Oriental Medicine, Kyung-Won University) ;
- Song, Yun-Kyung (Dept. of Rehabilitation Medicine, College of Oriental Medicine, Kyung-Won University)
- 발행 : 2007.03.30
초록
Objective : The objective of this study was to investigate the antioxidant effects of Mori Folium extract. Methods Total antioxidant status was examined by total antioxidant capacity(TAC) and total antioxidant response(TAR) against potent free radical reactions. The effect of Mori Folium extract was examined by measuring total phenolic content, concentration at which 1,1-dipheny1-2-picrylhydrazyl(DPPH) radical scavenging activity was inhibited, inhibitory effect on lipid peroxidation, and the effect on reactive oxygen species(ROS) generation. Results : 1. TAC and TAR of Mori Folium extract at the concentration of 5 mg/ml were 1.61 and 1.24 mM Trolox equivalents, respectively. 2. Total phenolic content of Mori Folium extract at the concentration of 5 mg/Ml was 1.70 mM gallic acid equivalent. 3. Concentration of Mori Folium extract at which DPPH radical scavenging activity was inhibited by 50% was 2.29 m9/m4 as compared to 100% by Pyrogallol solution as a reference. 4. The inhibitory effect of the extract on lipid peroxidation was examined using rat liver mitochondria induced by FeSO