Biomolecules & Therapeutics

  • 제15권1호
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  • Pages.52-57
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  • 2007
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  • 1976-9148(pISSN)
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  • 2005-4483(eISSN)
한국응용약물학회 (The Korean Society of Applied Pharmacology)
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Effects of Proton on Lysolipid-induced Actions in OGR1-subfamily GPCRs

  • Lim, Sung-Mee (Department of Food Science & Technology, Tongmyong University) ;
  • Im, Dong-Soon (Laboratory of Pharmacology, College of Pharmacy (BK2l Project) and Research Institute of Drug Development, Pusan National University)
  • 발행 : 2007.03.30
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초록

Lysolipids such as lysophosphatidylcholine (LPC), sphingosylphosphorylcholine (S PC), galactosylsphingosine (psychosine) have been matched as ligands for OGR1-subfamily G-protein-coupled receptors (GPCR), consisted of OGR1, GPR4, G2A, and TDAG8. Recently, those members of GPCRS have been reported as proton-sensing GPCRs. We used Jurkat T cells, which express four members of OGR1 subfamily GPCRs endogenously to investigate effects of proton on lysolipid-induced several cellular events. We found no significant effect of proton on the lysolipid-induced $Ca^{2+}$ increase and ROS production in Jurkat T cells. Further investigation is necessary to clarify the relationship of lysolipid and proton on the OGR1-subfamily GPCRs.

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