Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Evaluation of Antidiabetic and Antihyperlipidemic Activity of Luffa tuberosa (Roxb.) Fruits in Streptozotocin Induced Diabetic Rats

  • Yeligar, Veerendra C. (K.L.E. Society's College of Pharmacy, Division of Medicinal Chemistry, Dept. of Pharmaceutical Technology, Jadavpur University) ;
  • Murugesh, K. (Division of Medicinal Chemistry, Dept. of Pharmaceutical Technology, Jadavpur University) ;
  • Dash, Deepak Kumar (Division of Medicinal Chemistry, Dept. of Pharmaceutical Technology, Jadavpur University) ;
  • Nayak, Siva Shankar (Division of Medicinal Chemistry, Dept. of Pharmaceutical Technology, Jadavpur University) ;
  • Maiti, B. C. (Indian Institute of Chemical Biology) ;
  • Maity, Tapan K. (Division of Medicinal Chemistry, Dept. of Pharmaceutical Technology, Jadavpur University)
  • Published : 2007.03.31
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Abstract

Fresh unripe whole fruits of Luffa tuberosa (Roxb.) or Momordica tuberosa (Roxb.) Cogn. (Cucurbitaceae) were evaluated for the antidiabetic and hyperlipidemic potential in streptozotocin (STZ) induced diabetic rats. Diabetes was induced by administration of intra-peritoneal injection of streptozotocin at a dose of 55 mg/kg body weight. After the induction of diabetes aqueous extract of L.tuberosa (AELT) was administered orally at doses of 250 and 500 mg/kg. body weight/day for a period of 14 days. The Fasting blood glucose (FBG) levels, serum insulin levels, changes in body weight, food and liquid intake were measured. In diabetic rats, the AELT exhibited significant reduction in blood glucose levels. Biochemical assay of plasma total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc), glycogen content and glucose-6-phosphatase activity in liver were assessed. Antihyperlipidemia in diabetic rats after the extract supplementation was confirmed by significant reduction in the levels of above mentioned hyperlipidemic indicators. This study focus on the efficacy of L.tuberosa fruits for the management of experimental STZ induced diabetic rats and provides the scientific basis of ancient herbal therapy and use of these fruits as vegetable.

Keywords

References

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