Antiinflammatory, Analgesic and Hepatoprotective Effects of Aerial part of Viburum sargentii for. sterile

불두화 지상부의 진통소염작용 및 간 보호 효과

  • Published : 2007.03.31

Abstract

Leaves and stem of Viburnum sargentii for. sterile(Caprifoliaceae) has been used as therapeutic agents as a pain of the joints, skin disease as styptics, analgesics for traditional folk medicines. The present study describes the preliminary evaluation of biological activities-analgesic, anti-inflammatory, hepatoprotective activities, of its methanol extract, ethyl acetate fraction and butanol fraction. Among them butanol fraction showed the highest activity in inflammation and writhing test.

Keywords

References

  1. 이창복 (1982) 대한식물도감, 298 향문사, 서울
  2. 안덕균 (1998) 한국 본초도감, 318 교학사, 서울
  3. 김창민 등 (1997) 완역 중약대사전, 247, 248 도서출판 정담, 서울
  4. Plouvier, V. (1992) Bulletin du Museum National du Museum d' Histoire Naturelle (vols. 3-4e ser., section B). Paris, Adansonia, 461
  5. Glasby G.S. (1991) Dictionary of Plants Containing Secondary Metabolites, 336 Taylor and Francis, London
  6. Jensen,S.R. Nielsen B.J. and Norn V. (1985) Iridoids from Viburnum betulifolium, Phytochemistry 24: 487-489 https://doi.org/10.1016/S0031-9422(00)80753-0
  7. Mohamed M.A., Marzouk M.S., Moharram F.A., El-Sayed M.M. and Baiuomy A.R. (2005) Phytochemical constituents and hepatoprotective activity of Viburnum tinus Phytochemistry 66: 2780-2786 https://doi.org/10.1016/j.phytochem.2005.07.019
  8. Fukuyama Y., Minami H., Kagawa M., Kodama M. and Kawazu K. (1999) Chemical conversion of vibsanin C to vibsanin E and structure of 3-hydroxy-vibsanin E from Viburnum awabuki, J. Nat. Prod. 62: 337-339 https://doi.org/10.1021/np980338v
  9. Kubo M., Chen I.S. and Fukuyama Y. (2001) Vibsane-type diterpenes from Taiwanese Viburum odoratissimum. Chem. Pharm. Bull. 49: 242-245 https://doi.org/10.1248/cpb.49.242
  10. Tomassini L., Gao J., Serafini M. and Nicoletti M. (2005) Iridoid glucoside from Viburnum sargentii. Nat. Prod. Res. 19: 667-671 https://doi.org/10.1080/1478641042000301702
  11. Shen Y.C., Lin C.L., Chien S.C., Khalil A.T., Ko C.L. and Wang C.H. (2004) Vibsane diterpenoids from leaves and flowers of Viburnum odoratissimum. J. Nat. Prod. 67: 74-77 https://doi.org/10.1021/np030173c
  12. Nocholson J.A., Darby T.D. and Jarboe C.H. (1972) Viopudial, a hypotensive and smooth muscle antispasmodic from Vibrunum opulus. Proc. Soc. Exp. Biol. Med. 140: 457-461
  13. Young, J.M., Spires, D.A., Bedord, C.J., Wagner, B., De Ballaron, S.J. and Young, L.M. (1984) The mouse ear inflammatoryresponse to topical arachidonic acid. J. Invest. Dermatol., 82: 367-371 https://doi.org/10.1111/1523-1747.ep12260709
  14. Rao, T.S., Currie, J.L., Shaffer, A.F. and Isakson, P.C. (1993) Comparative evaluation of arachidonic acid (AA)-and Tetradecanoylphobol acetate (TPA)-induced dermal inflammation. Inflammation 17: 723-741 https://doi.org/10.1007/BF00920477
  15. Winter, C.A., Risley, E.A. and Nuss, G.W. (1962) Carrageenan- induced edema in hind paw of the rat as assay for anti-inflammatory drugs. Pro. Soc. Exp. Biol. 111: 544-547
  16. Nakamura, H., Yokoyama, Y., Motoyoshi, S., Seto, Y., Kadokawa, T. and Shimizu, T. (1982) Anti-inflammatory activity of a non-steroidal anti-inflammatory agent, zomepirac sodium, in experimental animals. Yakugaku Zasshi 79: 509- 527
  17. Whittle, B.A. (1964) The use of changes in capillary permeability in mice to distinguish between narcotic and nonnarcotic analgesics. Br. J. Pharmaco. Chemother 22: 246-253 https://doi.org/10.1111/j.1476-5381.1964.tb02030.x
  18. Mclean A.E. (1967) The effect of diet and vitamin E on liver injury due to carbon tetrachloride. Br. J. Exp. Pathol. 48: 632-636
  19. Di Rosa M., Giroud J.P. and Willoughby, D.A. (1971) Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J. Pathol. 104: 15-29 https://doi.org/10.1002/path.1711040103
  20. Gilligan, J.P., Lovato, S.J., Erior, M.D. and Jeng, A.Y. (1994) Modulation of carrageenan-induced hind paw edema by substance P. Inflammation 18: 285-292 https://doi.org/10.1007/BF01534269
  21. Bileviciute, I., Lundeberg, T., Ekblom, A. and Theodorsson, E. (1993) Bilateral changes of substance P-, neurokinin A-, calcitonin gene-related peptide- and neuropeptide Y-like immunoreactivity in rat knee joint synovial fluid during acute monoarthritis. Neurosci. Lett. 153: 37-40 https://doi.org/10.1016/0304-3940(93)90071-R
  22. Brittain R.T., Lehrer D.N. and Spencer, P.S. (1963) Phenylquinone writhing test Interpretation of data. Nature 200: 895-8964
  23. Zhang, B.H., Gong, D.Z. and Mei, M.H. (1999) Protection of regenerating liver after partial hepatectomy from carbon tetrachloride hepatotoxicity in rat: Role of hepatic stimulator substance. J. Gastroenterol. Hapato. 14: 1010-1017 https://doi.org/10.1046/j.1440-1746.1999.01992.x
  24. Plaa, G.L. and Hewitt, W.R. (1989) Detection and evaluation of chemically induced liver injury. Principles and Methods of Toxicology ed. by A.W. Hayes 599-628 Raven Press, New York