Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Antidiabetic Effect of Herbal Formula Containing Mori Folium, Euonymi Lignum Suberalatum and Ginseng Radix in db/db Mice

db/db 마우스에서 상엽, 귀전우, 인삼 복합처방의 항당뇨 활성

  • Park, Keum-Ju (Pharmacology and Clinical Pharmacy Lab., School of Pharmacy, Kyung Hee University) ;
  • Han, Eun-Jung (Pharmacology and Clinical Pharmacy Lab., School of Pharmacy, Kyung Hee University) ;
  • Choi, Yun-Sook (Pharmacology and Clinical Pharmacy Lab., School of Pharmacy, Kyung Hee University) ;
  • Han, Gi-Cheol (Pharmacology and Clinical Pharmacy Lab., School of Pharmacy, Kyung Hee University) ;
  • Park, Jong-Seok (Pharmacology and Clinical Pharmacy Lab., School of Pharmacy, Kyung Hee University) ;
  • Chung, Sung-Hyun (Pharmacology and Clinical Pharmacy Lab., School of Pharmacy, Kyung Hee University)
  • 박금주 (경희대학교 약학대학 약물학 임상약학교실) ;
  • 한은정 (경희대학교 약학대학 약물학 임상약학교실) ;
  • 최윤숙 (경희대학교 약학대학 약물학 임상약학교실) ;
  • 한기철 (경희대학교 약학대학 약물학 임상약학교실) ;
  • 박종석 (경희대학교 약학대학 약물학 임상약학교실) ;
  • 정성현 (경희대학교 약학대학 약물학 임상약학교실)
  • Published : 2007.03.31
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Abstract

Type 2 diabetes mellitus relavant to insulin resistance is a chronic and hard to control. In order to develop an antidiabetic agent from natural products, anti-hyperglycemic effect of herbal formula containing Mori Follium, Euonymi Lignum Suberalatum and Ginseng Radix(MEG) was investigated in db/db mice. Treatment group was administered orally with MEG formula at a dose of 300 mg/kg for 5 weeks, and blood glucose, insulin and lipid levels were determined. MEG treatment group showed a marked decrease in fasting blood glucose level and insulin resistance index(IRI) compared to those in diabetic control. Improvement of insulin resistance(60.6%) was indicative of reducing lipid levels in plasma and triglyceride contents in muscle and adipose tissue. In addition, expressions of an insulin responsive gene, glucose transporter 4(Glut4), in muscle and adipose tissue were upregulated in MEG treatment group. Compared islet morphology between groups, MEG formula prevented the ${\beta}$-cell destruction caused by high blood glucose. Taken together, MEG formula can act as an anti-hyperglycemic agent with insulin sensitizing effect, and thus deserves a clinical trial in the future.

Keywords

References

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