KSBB Journal

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Screening of Photosensitizer for Photodynamic Therapy

광역동 항암치료를 위한 광과민제 스크리닝 연구

  • Kim, So-Young (Department of Food and Biotechnology, and Center for Food Function and Safety, Hoseo University) ;
  • Yoo, Gui-Jae (Department of Food and Biotechnology, and Center for Food Function and Safety, Hoseo University) ;
  • Park, Keun-Hyoung (Department of Food and Biotechnology, and Center for Food Function and Safety, Hoseo University) ;
  • Lim, Byung-Lak (H&BT Korea Co., Ltd) ;
  • Kim, Shi-Surk (CMS Technology Co., Ltd) ;
  • Yom, Heng-Cherl (Department of Life Science, Hoseo University) ;
  • Chae, Hee-Jeong (Department of Food and Biotechnology, and Center for Food Function and Safety, Hoseo University)
  • 김소영 (호서대학교 식품생물공학과 및 식품기능안전연구센터) ;
  • 유귀재 (호서대학교 식품생물공학과 및 식품기능안전연구센터) ;
  • 박근형 (호서대학교 식품생물공학과 및 식품기능안전연구센터) ;
  • 임병락 ((주)에이치앤비티코리아) ;
  • 김시석 (CMS테크놀로지(주)) ;
  • 염행철 (호서대학교 생명과학과) ;
  • 채희정 (호서대학교 식품생물공학과 및 식품기능안전연구센터)
  • Published : 2007.10.30
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Abstract

Photodynamic therapy (PDT) is a targeted-tumor treatment system using a photosensitizer, light and oxygen to treat malignant tumor. We have investigated the cytotoxicity of 4 types of phthalocyanine derivative (silver phthalocyanine, iron (III) phthalocyanine, copper (II) phthalocyanine, nickel (II) phthalocyanine) against lung and breast cancers based on photodynamic therapy. As a result, phthalocyanine derivatives indicated a higher anticancer activity on a breast cancer cell line. Among the tested phthalocyanines, silver phthalocyanine (AgPc) showed a lower cytotoxicity against a normal cell line. In addition AgPc gave a good color characteristic when it is solubilized in water. Finally AgPc was selected as a potential antitumor agent for breast cancer.

광역동요법 (photodynamic therapy, PDT)은 악성종양을 치료하기 위해 광과민제와 레이저광을 이용하는 표적지향적 항암치료법이다. 본 연구에서는 PDT에 적용할 수 있는 새로운 광과민제를 스크리닝하기 위해 4종의 phthalocyanine계 광과민제 (silver phthalocyanine, iron (III) phthalocyanine, copper (II) phthalocyanine, nickel (II) phthalocyanine)을 이용하여 폐암과 유방암 세포주에 대한 항암활성 테스트를 수행하였다. 연구결과 phthalocyanine계 광과민제들은 폐암보다 유방암에 높은 활성을 나타냈으며, 그 중 silver phthalocyanine (AgPc)는 정상세포에 대해서는 세포독성이 낮으면서도 물에 용해할 경우 청색증을 유발하지 않아 유방암에 대한 항암제로서의 개발가능성을 확인하였다.

Keywords

References

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